Journal article
Diverse migratory pathways in the developing cerebral cortex
Science (American Association for the Advancement of Science), Vol.258(5080), pp.299-302
1992
DOI: 10.1126/science.1411527
PMID: 1411527
Abstract
During early development of the mammalian cerebral cortex, young neurons migrate outward from the site of their final mitosis in the ventricular zone into the cortical plate, where they form the adult cortex. Time-lapse confocal microscopy was used to observe directly the dynamic behaviors of migrating cells in living slices of developing cortex. The majority of cells migrated along a radial pathway, consistent with the view that cortical neurons migrate along radial glial fibers. A fraction of cells, however, turned within the intermediate zone and migrated orthogonal to the radial fibers. This orthogonal migration may contribute to the tangential dispersion of clonally related cortical neurons.
Details
- Title: Subtitle
- Diverse migratory pathways in the developing cerebral cortex
- Creators
- Nancy A O'Rourke - Stanford univ., dep. biological sci., Stanford CA 94305, United StatesMichael E Dailey - Stanford univ., dep. biological sci., Stanford CA 94305, United StatesStephen J Smith - Stanford univ., dep. biological sci., Stanford CA 94305, United StatesSusan K McConnell - Stanford univ., dep. biological sci., Stanford CA 94305, United States
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.258(5080), pp.299-302
- Publisher
- American Association for the Advancement of Science; Washington, DC
- DOI
- 10.1126/science.1411527
- PMID
- 1411527
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 1992
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984070861902771
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