Journal article
Diversity and complexity of auditory representation in the hearing systems of Aedes aegypti mosquitoes
Science advances, Vol.11(23), eads2689
06/04/2025
DOI: 10.1126/sciadv.ads2689
PMCID: PMC12136032
PMID: 40465714
Abstract
Although low-frequency sounds have been reported to stimulate dispersal responses in male and female mosquitoes, only males show attraction to sound. Male attraction to female flight tones is important during courtship; however, groups of males show diverse responses to acoustic stimuli, suggesting that auditory processing can vary drastically between the sexes and individual males. To investigate diversity in auditory representation within and between the sexes, we used molecular and functional analyses to explore
mosquito auditory processing. We identified shared and dimorphic neurons connecting mosquito ears to the brains' primary auditory processing center. Calcium imaging from this brain region facilitated definition of multiple neuronal clusters based on auditory stimulation responses. More clusters with greater complexity were identified in males than females, with these clusters highly differentiated among males. Transcriptomic and proteomic analyses found enrichment of ciliary-related factors in male ears compared to females, potentially underlying sexual dimorphisms in hearing systems.
Details
- Title: Subtitle
- Diversity and complexity of auditory representation in the hearing systems of Aedes aegypti mosquitoes
- Creators
- Takuro S Ohashi - Nagoya UniversityYifeng Y J Xu - Nagoya UniversityShunsuke Shigaki - National Institute of InformaticsYukiko Nakamura - Nagoya UniversityTai-Ting Lee - Nagoya UniversityYuMin M Loh - Nagoya UniversityEmi Mishiro-Sato - Nagoya UniversityDaniel F Eberl - University of IowaMatthew P Su - Nagoya UniversityAzusa Kamikouchi - Nagoya University
- Resource Type
- Journal article
- Publication Details
- Science advances, Vol.11(23), eads2689
- DOI
- 10.1126/sciadv.ads2689
- PMID
- 40465714
- PMCID
- PMC12136032
- NLM abbreviation
- Sci Adv
- ISSN
- 2375-2548
- eISSN
- 2375-2548
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Grant note
- MEXT KAKENHI: JP24H02200, JP23K19365, JP22K15159 JST FOREST: JPMJFR2147 Human Frontier Science Program Organization: RGP0033/2021 Nagoya University Tokai Pathways to Global Excellence: 0121AN0002 JSPS Invitational Fellowships for Research in Japan: S22091 International Principal Investigator (PI) Invitation Program, Nagoya University, Japan
This work was supported by the MEXT KAKENHI Grant-in-Aid for transformative Research Areas (A) "Materia- Mind" JP24H02200 (A.K.), JST FOREST JPMJFR2147 (A.K.), Human Frontier Science Program Organization RGP0033/2021 (A.K.), MeXt KAKenhi Grant- in-Aid for Research Activity Start- up JP23K19365 (t.S.O.), MeXt KAKenhi Grant- in-Aid for Research Activity Start- up JP22K15159 (M.P.S.), Nagoya University Tokai Pathways to Global Excellence 0121AN0002 (M.P.S.), JSPS Invitational Fellowships for Research in Japan (Short- term) S22091 (d.F.e.), and International Principal Investigator (PI) Invitation Program, Nagoya University, Japan (to d.F.e.).
- Language
- English
- Date published
- 06/04/2025
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984828224502771
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