Diversity of Bile Salts in Fish and Amphibians: Evolution of a Complex Biochemical Pathway

Lee R Hagey; Peter R Møller; Alan F Hofmann; Matthew D Krasowski

doi:10.1086/649966

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Diversity of Bile Salts in Fish and Amphibians: Evolution of a Complex Biochemical Pathway

Journal article

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Peer reviewed

Diversity of Bile Salts in Fish and Amphibians: Evolution of a Complex Biochemical Pathway

Lee R Hagey, Peter R Møller, Alan F Hofmann and Matthew D Krasowski

Physiological and biochemical zoology, Vol.83(2), pp.308-321

2010

DOI: 10.1086/649966

PMCID: PMC2845723

PMID: 20113173

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Abstract

Bile salts are the major end-metabolites of cholesterol and are also important in lipid and protein digestion, as well as shaping of the gut microflora. Previous studies had demonstrated variation of bile salt structures across vertebrate species. We greatly extend prior surveys of bile salt variation in fish and amphibians, particularly in analysis of the biliary bile salts of Agnatha and Chondrichthyes. While there is significant structural variation of bile salts across all fish orders, bile salt profiles are generally stable within orders of fish and do not correlate with differences in diet. This large data set allowed us to infer evolutionary changes in the bile salt synthetic pathway. The hypothesized ancestral bile salt synthetic pathway, likely exemplified in extant hagfish, is simpler and much shorter than the pathway of most teleost fish and terrestrial vertebrates. Thus, the bile salt synthetic pathway has become longer and more complex throughout vertebrate evolution. Analysis of the evolution of bile salt synthetic pathways provides a rich model system for the molecular evolution of a complex biochemical pathway in vertebrates.

hagfishes

enzymes

mass spectrometry

steroids

molecular evolution

Cholesterol

Details

Title: Subtitle: Diversity of Bile Salts in Fish and Amphibians: Evolution of a Complex Biochemical Pathway
Creators: Lee R Hagey - Department of Medicine, University of California at San Diego, MC 0063, La Jolla, California 92093-0063
Peter R Møller - National History Museum of Denmark, Zoological Museum, University of Copenhagen, Denmark
Alan F Hofmann - Department of Medicine, University of California at San Diego, MC 0063, La Jolla, California 92093-0063
Matthew D Krasowski - Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261
Resource Type: Journal article
Publication Details: Physiological and biochemical zoology, Vol.83(2), pp.308-321
DOI: 10.1086/649966
PMID: 20113173
PMCID: PMC2845723
NLM abbreviation: Physiol Biochem Zool
ISSN: 1522-2152
eISSN: 1537-5293
Language: English
Date published: 2010
Academic Unit: Pathology
Record Identifier: 9984046935302771

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