Journal article
Do Pulmonary Ionocytes Absorb Chloride or Secrete Chloride?
American Journal of Physiology: Cell Physiology, Vol.328(2), pp.C400-C403
02/01/2025
DOI: 10.1152/ajpcell.00672.2024
PMCID: PMC12186486
PMID: 39716827
Abstract
Pulmonary ionocytes express high levels of cystic fibrosis transmembrane conductance regulator (CFTR) channels. When studied using the short-circuit current technique, ionocytes produce CFTR-dependent short-circuit currents consistent with Cl
secretion. However, when studied without a voltage-clamp, data indicate that ionocytes absorb Cl
. In this review, we resolve these seemingly conflicting findings by considering the different transepithelial voltages and resultant movement of Cl
during short-circuit and physiological open-circuit conditions. This analysis indicates that behavior under short-circuit conditions cannot be directly extrapolated to infer behavior under physiologic conditions. Finally, we discuss the potential role for basolateral Cl
channels in controlling absorption and secretion in ionocytes.
Details
- Title: Subtitle
- Do Pulmonary Ionocytes Absorb Chloride or Secrete Chloride?
- Creators
- Ian M Thornell - University of IowaLei Lei - University of IowaPaul B McCray Jr - University of Iowa, Pulmonary MedicineMichael J Welsh - University of Iowa
- Resource Type
- Journal article
- Publication Details
- American Journal of Physiology: Cell Physiology, Vol.328(2), pp.C400-C403
- DOI
- 10.1152/ajpcell.00672.2024
- PMID
- 39716827
- PMCID
- PMC12186486
- NLM abbreviation
- Am J Physiol Cell Physiol
- ISSN
- 1522-1563
- eISSN
- 1522-1563
- Publisher
- AMER PHYSIOLOGICAL SOC
- Grant note
- HL152960 / HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL147366 / HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) THORNE24G0 / Cystic Fibrosis Foundation (CFF) HL171035 / HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) Howard Hughes Medical Institute (HHMI) HL091842 / HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) MCCRAY23G0 / Cystic Fibrosis Foundation (CFF) Roy J. Carver Charitable Trust (RJCCT)
- Language
- English
- Electronic publication date
- 12/23/2024
- Date published
- 02/01/2025
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Microbiology and Immunology; Critical Care; Pulmonary Medicine; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Internal Medicine
- Record Identifier
- 9984759115502771
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