Do associations with hand OA vary by knee osteoarthritis phenotype? Cross-sectional data from the Multicenter Osteoarthritis Study

Michelle S. Yau; Helgi Jonsson; John A. Lynch; Cora E. Lewis; James C. Torner; Michael C. Nevitt; David T. Felson

doi:10.1016/j.ocarto.2022.100331

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Do associations with hand OA vary by knee osteoarthritis phenotype? Cross-sectional data from the Multicenter Osteoarthritis Study

Journal article

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Do associations with hand OA vary by knee osteoarthritis phenotype? Cross-sectional data from the Multicenter Osteoarthritis Study

Michelle S. Yau, Helgi Jonsson, John A. Lynch, Cora E. Lewis, James C. Torner, Michael C. Nevitt and David T. Felson

Osteoarthritis and cartilage open, Vol.5(1), p.100331

03/2023

DOI: 10.1016/j.ocarto.2022.100331

PMCID: PMC9807822

PMID: 36605850

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Abstract

Osteoarthritis (OA) is highly heterogeneous and has both biomechanical and systemic components that may not have the same etiology. We therefore aimed to identify specific knee OA phenotypes that may be more strongly associated with hand OA to refine the criteria used to define multi-joint OA. We assessed data from the Multicenter Osteoarthritis Study (MOST). We ascertained hand OA from bilateral hand photographs; scores for each joint row were summed to yield an aggregate hand OA score. Knee OA was ascertained from bilateral posteroanterior knee radiographs read for Kellgren-Lawrence grade and individual radiographic features. We tested associations between hand and knee OA with phenotypes including symptomatic OA, hyper- and atrophic knee OA, and one excluding post-traumatic OA. Associations between hand and knee OA were assessed with logistic regression, adjusted for age. We studied 2493 participants with hand and knee OA measures. Median age was 63 years with 57% women. 55% had an aggregate hand OA score ≥2; frequency of knee OA phenotypes ranged from 8% to 34%. The age-adjusted odds ratio (OR) was 1.14 (95% confidence interval (CI) = 1.04–1.26) for knee OA per standard deviation of the hand OA aggregate score. Hand OA associations with symptomatic knee OA and knee OA excluding post-traumatic knee OA were OR = 1.16 (95% CI = 1.03–1.31) and OR = 1.21 (95% CI = 1.08–1.35), respectively. No other knee OA phenotype reached statistical significance. Age-adjusted associations between hand and knee OA were modest and were largely similar across knee OA phenotypes.

Multi-joint OA

Pain

Post-traumatic OA

Details

Title: Subtitle: Do associations with hand OA vary by knee osteoarthritis phenotype? Cross-sectional data from the Multicenter Osteoarthritis Study
Creators: Michelle S. Yau - Hebrew SeniorLife
Helgi Jonsson - University of Iceland
John A. Lynch - University of California, San Francisco
Cora E. Lewis - University of Alabama
James C. Torner - University of Iowa
Michael C. Nevitt - University of California, San Francisco
David T. Felson - Boston University School of Medicine
Resource Type: Journal article
Publication Details: Osteoarthritis and cartilage open, Vol.5(1), p.100331
DOI: 10.1016/j.ocarto.2022.100331
PMID: 36605850
PMCID: PMC9807822
NLM abbreviation: Osteoarthr Cartil Open
ISSN: 2665-9131
eISSN: 2665-9131
Publisher: Elsevier Ltd
Language: English
Date published: 03/2023
Academic Unit: Neurology; Epidemiology; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9984355059502771

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