Journal article
Do dorsal root reflexes augment peripheral inflammation?
Neuroreport, Vol.5(7), pp.821-824
03/1994
DOI: 10.1097/00001756-199403000-00021
PMID: 8018857
Abstract
EFFERENT activity was recorded in knee joint afférents in response to mechanical stimulation of the hindlimb following induction of acute arthritis. The activity was abolished by application of lidocaine or crushing the nerve proximally and by dorsal rhizotomy but not by sympathectomy. It was concluded that this activity represents dorsal root reflexes in response to natural stimulation of the hindlimb. We propose that increased activity of articular afférents and of dorsal horn neurons during arthritis results in the pathological activation of the central terminals of primary afférents by enhancing primary afferent depolarization. Dorsal root reflexes could then release substances in the knee joint and thus contribute to the acute inflammatory response.
Details
- Title: Subtitle
- Do dorsal root reflexes augment peripheral inflammation?
- Creators
- Huw Rees - Department of Anatomy and Neurosciences, The University of Texas Medical Branch, Galveston, Texas 77550–0843, USA CA Corresponding AuthorKathleen SlukaKarin WestlundWilliam Willis
- Resource Type
- Journal article
- Publication Details
- Neuroreport, Vol.5(7), pp.821-824
- Publisher
- Lippincott-Raven Publishers
- DOI
- 10.1097/00001756-199403000-00021
- PMID
- 8018857
- ISSN
- 0959-4965
- eISSN
- 1473-558X
- Language
- English
- Date published
- 03/1994
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984040201402771
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