Journal article
Do pulmonary cavity shapes influence lung function?
Journal of biomechanical engineering, Vol.141(11), 111005
06/24/2019
DOI: 10.1115/1.4044092
PMID: 31233096
Abstract
Distribution of lung tissue within the chest cavity is a key contributor to delivery of both blood and air to the gas exchange regions of the lung. This distribution is multifactorial with influences from parenchyma, gravity and level of inflation. We hypothesize that the manner in which lung inflates, for example, the primarily diaphragmatic nature of normal breathing, is an important contributor to regional lung tissue distribution. To investigate this hypothesis, we present an organ-level model of lung tissue mechanics which incorporates pleural cavity change due to change in lung volume or posture. We quantify the changes using shape and density metrics in ten healthy subjects scanned supine at end-inspiratory and end-expiratory volumes and ten subjects scanned at both supine and prone end-inspiratory volumes. Comparing end-expiratory to end-inspiratory volume, we see primarily a change in the cranial-caudal dimension of the lung, reflective of movement of diaphragm. In the diaphragmatic region there is greater regional lung expansion than in the cranial aspect, which is restricted by the chest wall. When moving from supine to prone, a restriction of lung was observed anteriorly, resulting in a generally reduced lung volume and a redistribution of air volume posteriorly. In general, we see the highest in lung tissue density heterogeneity in regions of the lung that are most inflated. Using our computational model, we quantify the impact of pleural cavity shape change on regional lung distribution, and predict the impact on regional elastic recoil pressure.
Details
- Title: Subtitle
- Do pulmonary cavity shapes influence lung function?
- Creators
- Hamed Minaeizaeim - University of AucklandHaribalan Kumar - University of AucklandMerryn Tawhai - University of AucklandClair King - Auckland City HospitalEric Hoffman - University of IowaMargaret Wilsher - Auckland City HospitalDavid Milne - Auckland City HospitalAlys Clark - University of Auckland
- Resource Type
- Journal article
- Publication Details
- Journal of biomechanical engineering, Vol.141(11), 111005
- DOI
- 10.1115/1.4044092
- PMID
- 31233096
- ISSN
- 0148-0731
- eISSN
- 1528-8951
- Grant note
- P30 DK054759 / NIDDK NIH HHS
- Language
- English
- Date published
- 06/24/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984318785902771
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