Do worsening knee radiographs mean greater chances of severe functional limitation?

Daniel K White; Yuqing Zhang; Jingbo Niu; Julie J Keysor; Michael C Nevitt; Cora E Lewis; James C Torner; Tuhina Neogi

doi:10.1002/acr.20247

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Do worsening knee radiographs mean greater chances of severe functional limitation?

Journal article

Open access

Peer reviewed

Do worsening knee radiographs mean greater chances of severe functional limitation?

Daniel K White, Yuqing Zhang, Jingbo Niu, Julie J Keysor, Michael C Nevitt, Cora E Lewis, James C Torner and Tuhina Neogi

Arthritis care & research (2010), Vol.62(10), pp.1433-1439

10/2010

DOI: 10.1002/acr.20247

PMCID: PMC2939286

PMID: 20506398

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Abstract

Development of functional limitation is thought to be unrelated to changes in severity of radiographic osteoarthritis (OA) of the knee. We evaluated the relationship of change in radiographic OA to the incidence of severe functional limitation. Participants of the Multicenter Osteoarthritis Study, a cohort study of persons with or at high risk of knee OA, were evaluated at 0 and 30 months. Subjects were classified as having no, incident, stable, or worsening radiographic OA. Incidence of severe functional limitation was defined by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function scores (≥36.1/68) and walking speed (≤1.0 meter/second) at 30 months. The relationship of the change in radiographic OA to the incidence of severe functional limitation was evaluated by calculating risk ratios adjusted for potential confounders. Of the 2,210 subjects included (mean age 62 years, mean body mass index 30 kg/m², 60% women), 53% had no, 6% had incident, 14% had stable, and 27% had worsening radiographic OA. Persons with incident radiographic OA had 1.9 and 1.8 times the risk by WOMAC physical function score and walking speed, respectively, to have incident severe functional limitation compared with those with no radiographic OA over 30 months. Compared with those with stable radiographic OA, persons with worsening radiographic OA had 2.2 and 2.3 times the risk of incident severe functional limitation, respectively. Changes in structural disease are associated with the development of severe functional limitations in persons with or even at high risk of knee OA.

Severity of Illness Index

Prospective Studies

Humans

Middle Aged

Knee Joint - diagnostic imaging

Male

Osteoarthritis, Knee - diagnostic imaging

Disease Progression

Activities of Daily Living

Radiography

Knee Joint - physiology

Female

Aged

Osteoarthritis, Knee - physiopathology

Cohort Studies

Details

Title: Subtitle: Do worsening knee radiographs mean greater chances of severe functional limitation?
Creators: Daniel K White - Boston University School of Medicine, Massachusetts, USA. white.daniel@gmail.com
Yuqing Zhang
Jingbo Niu
Julie J Keysor
Michael C Nevitt
Cora E Lewis
James C Torner
Tuhina Neogi
Resource Type: Journal article
Publication Details: Arthritis care & research (2010), Vol.62(10), pp.1433-1439
DOI: 10.1002/acr.20247
PMID: 20506398
PMCID: PMC2939286
NLM abbreviation: Arthritis Care Res (Hoboken)
ISSN: 1529-0131
eISSN: 2151-4658
Publisher: United States
Grant note: U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS AR-47785 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS U01-AG18947 / NIA NIH HHS P60 AR047785 / NIAMS NIH HHS U01-AG18832 / NIA NIH HHS K23-AR055127 / NIAMS NIH HHS K23 AR055127 / NIAMS NIH HHS T32 AR007598 / NIAMS NIH HHS U01-AG19069 / NIA NIH HHS U01-AG18820 / NIA NIH HHS AR-47885 / NIAMS NIH HHS AR-007598 / NIAMS NIH HHS U01 AG018820 / NIA NIH HHS
Language: English
Date published: 10/2010
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995036502771

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