Journal article
Docetaxel Activity in the Era of Life-prolonging Hormonal Therapies for Metastatic Castration-resistant Prostate Cancer
European urology, Vol.70(3), pp.410-412
09/01/2016
DOI: 10.1016/j.eururo.2016.05.002
PMID: 27184379
Abstract
For >6 yr, docetaxel with prednisone was the only treatment with survival benefits for metastatic castration-resistant prostate cancer (mCRPC). More recently, in clinical practice, abiraterone acetate has been commonly administered prior to docetaxel for the treatment of mCRPC. Our study aimed to review the activity of docetaxel after prior abiraterone. To this end, we analyzed all retrospective reports in the literature describing the overall survival (OS) of mCRPC patients treated with docetaxel after previous abiraterone. The mean OS observed was 12.7 mo, which suggested a significant decrement compared with the 19.2 mo seen in the updated analysis of the TAX 327 study; however, the data are quite similar to the OS of 13.6 mo (95% confidence interval, 12.1–15.1 mo) described in a retrospective single-institution study of 357 men with mCRPC treated with docetaxel with no prior abiraterone mostly in routine practice (86.3%). Because the characteristics of patients recruited in phase 3 trials tend to differ from the real-world setting, we deemed this data set a relevant comparison. Consequently, despite the limitations of retrospective cross-study comparisons, the data suggest that docetaxel retains activity when used as second-line therapy after abiraterone for mCRPC patients.
We reviewed the activity of docetaxel after prior use of abiraterone and considered the results in the light of the outcomes of docetaxel used as first-line therapy for metastatic castration-resistant prostate cancer (mCRPC) patients in routine practice. We noted that docetaxel retains reasonable activity and is a useful agent for the treatment of mCRPC patients before or after abiraterone.
Mean overall survival from all retrospective reports of docetaxel after abiraterone in metastatic castration-resistant prostate cancer patients is similar to that of docetaxel used as first line in routine practice. Docetaxel has reasonable activity when used after abiraterone.
Details
- Title: Subtitle
- Docetaxel Activity in the Era of Life-prolonging Hormonal Therapies for Metastatic Castration-resistant Prostate Cancer
- Creators
- Edoardo Francini - Dana-Farber Cancer InstituteChristopher J. Sweeney - Dana-Farber Cancer Institute
- Resource Type
- Journal article
- Publication Details
- European urology, Vol.70(3), pp.410-412
- DOI
- 10.1016/j.eururo.2016.05.002
- PMID
- 27184379
- NLM abbreviation
- Eur Urol
- ISSN
- 0302-2838
- eISSN
- 1873-7560
- Publisher
- Elsevier B.V
- Number of pages
- 3
- Language
- English
- Date published
- 09/01/2016
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985221245002771
Metrics
1 Record Views