Does Autism Diagnosis Age or Symptom Severity Differ Among Children According to Whether Assisted Reproductive Technology was Used to Achieve Pregnancy?

Laura A. Schieve; Christine Fountain; Sheree L. Boulet; Marshalyn Yeargin-Allsopp; Dmitry M. Kissin; Denise J. Jamieson; Catherine Rice; Peter Bearman

doi:10.1007/s10803-015-2462-1

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Does Autism Diagnosis Age or Symptom Severity Differ Among Children According to Whether Assisted Reproductive Technology was Used to Achieve Pregnancy?

Journal article

Open access

Peer reviewed

Does Autism Diagnosis Age or Symptom Severity Differ Among Children According to Whether Assisted Reproductive Technology was Used to Achieve Pregnancy?

Laura A. Schieve, Christine Fountain, Sheree L. Boulet, Marshalyn Yeargin-Allsopp, Dmitry M. Kissin, Denise J. Jamieson, Catherine Rice and Peter Bearman

Journal of autism and developmental disorders, Vol.45(9), pp.2991-3003

09/01/2015

DOI: 10.1007/s10803-015-2462-1

PMCID: PMC4553150

PMID: 25997596

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Abstract

Previous studies report associations between conception with assisted reproductive technology (ART) and autism. Whether these associations reflect an ascertainment or biologic effect is undetermined. We assessed diagnosis age and initial autism symptom severity among >30,000 children with autism from a linkage study of California Department of Developmental Services records, birth records, and the National ART Surveillance System. Median diagnosis age and symptom severity levels were significantly lower for ART-conceived than non-ART-conceived children. After adjustment for differences in the socio-demographic profiles of the two groups, the diagnosis age differentials were greatly attenuated and there were no differences in autism symptomatology. Thus, ascertainment issues related to SES, not ART per se, are likely the driving influence of the differences we initially observed.

Assisted reproductive technology

Diagnosis age

Infantile autism

Original Paper

Symptom severity

Details

Title: Subtitle: Does Autism Diagnosis Age or Symptom Severity Differ Among Children According to Whether Assisted Reproductive Technology was Used to Achieve Pregnancy?
Creators: Laura A. Schieve - National Center on Birth Defects and Developmental Disabilities
Christine Fountain - Fordham University
Sheree L. Boulet - National Center for Chronic Disease Prevention and Health Promotion
Marshalyn Yeargin-Allsopp - National Center on Birth Defects and Developmental Disabilities
Dmitry M. Kissin - Centers for Disease Control and Prevention
Denise J. Jamieson - National Center for Chronic Disease Prevention and Health Promotion
Catherine Rice - National Center on Birth Defects and Developmental Disabilities
Peter Bearman - Columbia University
Resource Type: Journal article
Publication Details: Journal of autism and developmental disorders, Vol.45(9), pp.2991-3003
DOI: 10.1007/s10803-015-2462-1
PMID: 25997596
PMCID: PMC4553150
NLM abbreviation: J Autism Dev Disord
ISSN: 0162-3257
eISSN: 1573-3432
Publisher: Springer US
Grant note: name: NIH Director's Pioneer Award, award: 1 DP1 OD003635-01; DOI: 10.13039/100000025, name: National Institutes of Mental Health, award: R21MH096122
Language: English
Date published: 09/01/2015
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446443802771

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