Journal article
Does Celecoxib Have a Role in the Treatment of Patients with Colorectal Cancer?
Clinical colorectal cancer, Vol.8(1), pp.11-14
01/01/2009
DOI: 10.3816/CCC.2009.n.002
PMID: 19203891
Abstract
The outcome of advanced colorectal cancer (CRC) has steadily improved with the addition of several novel agents. However, chemotherapy is associated with significant toxicities such as diarrhea and bone marrow suppression. Celecoxib has been associated with decreased gastrointestinal toxicity and improved chemotherapy tolerance in preclinical in vivo models, resulting in its investigation in CRC clinical trials. These trials failed to show any improvements in efficacy or reduction in chemotherapy-induced toxicity. This article summarizes relevant preclinical and clinical investigations of celecoxib in CRC.
Details
- Title: Subtitle
- Does Celecoxib Have a Role in the Treatment of Patients with Colorectal Cancer?
- Creators
- Marwan G. Fakih - Roswell Park Cancer InstituteYoucef M. Rustum - Roswell Park Cancer Institute
- Resource Type
- Journal article
- Publication Details
- Clinical colorectal cancer, Vol.8(1), pp.11-14
- Publisher
- Cig Media Group, Lp
- DOI
- 10.3816/CCC.2009.n.002
- PMID
- 19203891
- ISSN
- 1533-0028
- eISSN
- 1938-0674
- Number of pages
- 4
- Language
- English
- Date published
- 01/01/2009
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984360049802771
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