Journal article
Does MMP-3 polymorphism have a role in the etiology of the posterior tibial tendinopathy?
Fuss & Sprunggelenk, Vol.15(2), pp.114-119
06/2017
DOI: 10.1016/j.fuspru.2017.02.001
Abstract
Several risk factors and systemic conditions have been proposed in the etiology of posterior tibial tendon (PTT) tendinopathy. However, many patients present PTT dysfunction without any of these characteristics. This suggests that there could be a genetic influence associated with posterior tibial tendinopathy.
The purpose of the present study was to investigate the association of the −1612 polymorphism in the promoter gene of matrix metalloproteinase 3 (MMP-3) and posterior tibial tendinopathy.
The study group included 68 women who presented with PTT dysfunction grade 2 or 3, and who underwent surgical treatment, with histopathological examination of the tendon and magnetic resonance imaging (MRI) confirming tendinopathy. The control group consisted of 100 asymptomatic women with an intact PTT on magnetic resonance imaging (MRI).
There was no statistically significant difference between the study and the control groups with respect to the presence of the different MMP-3 alleles and genotypes (Chi-square p value>0.05). The odds ratio analysis showed OR=1.9, p=0.31 for 5A/5A vs. 6A/6A and OR=1.8, p=0.29 for 5A/5A vs. 6A/5A.
The −1612 polymorphism of the promoter gene of MMP-3 is not solely associated with posterior tibial tendinopathy in the studied population.
Level of evidence: 3
Verschiedene Risikofaktoren und systemische Erkrankungen werden mit der Tendinopathie der Tibialis posterior Sehne (PTT) in Verbindung gebracht. Jedoch haben viele Patienten eine PTT-Dysfunktion ohne diese Merkmale. Dies führt zu der Annahme, dass es eine genetische Ursache für die Tendinopathie der Tibialis posterior-Sehne geben könnte.
Das Ziel dieser Studie war die Untersuchung der Assoziation des -1612 Polymorphismus im Promotor-Gen der Martix-Metalloproteinase 3 (MMP-3) mit der Tibialis posterior Tendinopathie.
Die Studiengruppe bestand aus 68 Frauen mit klinisch manifester PTT-Dysfunktion vom Grad 2 und 3, welche sich einer chirurgischen Korrektur unterzogen. Die Sehnen wurden histopathologisch und mittels Magnetresonanztomographie (MRT) untersucht Die Kontrollgruppe bestand aus 100 asymptomatischen Frauen ohne Pathologie der Tibialis posterior-Sehne.
Es fand sich kein statistisch signifikanter Unterschied zwischen der Studien- und der Kontrollgruppe für die verschiedenen MMP-3 Allele und Genotypen (p>0.05, Chi-Quadrat-Test). Die Odds Ratio-Analyse ergab OR=1.9, p=0.31 für 5A / 5A vs. 6A / 6A und OR=1.8, p=0.29 für 5A / 5A vs. 6A / 5A.
Der -1612 Polymorphismus im Promotor des Matrix-Metalloproteinase 3-Genes ist in der untersuchten Studienpopulation nicht alleinig mit der Tibialis posterior-Tendinopathie assoziiert.
Evidenzgrad: 3
Details
- Title: Subtitle
- Does MMP-3 polymorphism have a role in the etiology of the posterior tibial tendinopathy?
- Creators
- A.L Godoy-Santos - Department of Orthopedic and Traumatology, University of São Paulo, São Paulo, SP, BrazilT Diniz Fernandes - Department of Orthopedic and Traumatology, University of São Paulo, São Paulo, SP, BrazilB.F.S Massa - Department of Orthopedic and Traumatology, University of São Paulo, São Paulo, SP, BrazilC de Cesar-Netto - Department of Orthopedic, Medstar Union Memorial Hospital, Baltimore, MD, USAM.C Santos - Department of Cell Biology, University Federal of Paraná, Centro Politécnico, Curitiba, PR, BrazilS Rammelt - University Center for Orthopedics and Traumatology, Universitätsklinikum Carl Gustav Carus, Dresden, Germany
- Resource Type
- Journal article
- Publication Details
- Fuss & Sprunggelenk, Vol.15(2), pp.114-119
- Publisher
- Elsevier GmbH
- DOI
- 10.1016/j.fuspru.2017.02.001
- ISSN
- 1619-9987
- eISSN
- 1619-9995
- Grant note
- name: Godoy-Moreira Research Center
- Alternative title
- Die Rolle von MMP-3-Polymorphismus in der Tibialis Posterior Tendinopathie
- Language
- English
- Date published
- 06/2017
- Academic Unit
- Orthopedics and Rehabilitation
- Record Identifier
- 9984040438202771
Metrics
22 Record Views