Journal article
Does Maternal Exposure to Secondhand Tobacco Smoke During Pregnancy Increase the Risk for Preterm or Small-for-Gestational Age Birth?
Maternal and child health journal, Vol.22(10), pp.1418-1429
10/2018
DOI: 10.1007/s10995-018-2522-1
PMID: 29574536
Abstract
Introduction While associations between active smoking and various adverse birth outcomes (ABOs) have been reported in the literature, less is known about the impact of secondhand smoke (SHS) on many pregnancy outcomes. Methods We examined the relationship between maternal exposure to SHS during pregnancy and preterm (< 37 weeks gestation) and small-for-gestational age (SGA; assessed using sex-, race/ethnic-, and parity-specific growth curves) singleton births using non-smoking controls from the National Birth Defects Prevention Study (1997-2011). Multivariable logistic regression models for household, workplace/school, and combined SHS exposure-controlled for maternal education, race/ethnicity, pre-pregnancy body mass index, and high blood pressure-were used to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs). Interaction was assessed for maternal folic acid supplementation, alcohol use, age at delivery, and infant sex. Results Infants of 8855 mothers were examined in the preterm birth analysis with 666 (7.5%) categorized as preterm, 574 moderately preterm (32-36 weeks), and 92 very preterm (< 32 weeks). For the SGA analysis, infants of 8684 mothers were examined with 670 (7.7%) categorized as SGA. The aORs for mothers reporting both household and workplace/school SHS were elevated for preterm (aOR 1.99; 95% CI 1.13-3.50) and moderately preterm birth (32-36 weeks) (aOR 2.17; 95% CI 1.22-3.88). No results for the SGA analysis achieved significance, nor was evidence of interaction evident. Conclusion The findings suggest an association between SHS from multiple exposure sources and preterm birth, but no evidence for association with SGA births. Continued study of SHS and ABOs is needed to best inform public health prevention programs.
Details
- Title: Subtitle
- Does Maternal Exposure to Secondhand Tobacco Smoke During Pregnancy Increase the Risk for Preterm or Small-for-Gestational Age Birth?
- Creators
- Adrienne T Hoyt - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, 1100 W. 49th St., Austin, TX, 78714-9347, USA. adrienne.hoyt@dshs.texas.govMark A Canfield - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, 1100 W. 49th St., Austin, TX, 78714-9347, USAPaul A Romitti - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA, USALorenzo D Botto - Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USAMarlene T Anderka - Massachusetts Center for Birth Defects Research and Prevention, Massachusetts Department of Public Health, Boston, MA, USASergey V Krikov - Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USAMarcia L Feldkamp - Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA
- Resource Type
- Journal article
- Publication Details
- Maternal and child health journal, Vol.22(10), pp.1418-1429
- Publisher
- United States
- DOI
- 10.1007/s10995-018-2522-1
- PMID
- 29574536
- ISSN
- 1092-7875
- eISSN
- 1573-6628
- Grant note
- P30 ES005605 / NIEHS NIH HHS U01DD000494 / NCBDD CDC HHS U01 DD001035 / NCBDD CDC HHS U01 DD001223 / NCBDD CDC HHS DK56350 / Nutrition Epidemiology Core of the University of North Carolina Clinical Nutrition Research Center
- Language
- English
- Date published
- 10/2018
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9983996189502771
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