Does Oral Supplementation of a Fermented Papaya Preparation Correct Respiratory Burst Function of Innate Immune Cells in Type 2 Diabetes Mellitus Patients?

Ryan Dickerson; Jaideep Banerjee; Adam Rauckhorst; Douglas R. Pfeiffer; Gayle M. Gordillo; Savita Khanna; Kwame Osei; Sashwati Roy

doi:10.1089/ars.2014.6138

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Does Oral Supplementation of a Fermented Papaya Preparation Correct Respiratory Burst Function of Innate Immune Cells in Type 2 Diabetes Mellitus Patients?

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Does Oral Supplementation of a Fermented Papaya Preparation Correct Respiratory Burst Function of Innate Immune Cells in Type 2 Diabetes Mellitus Patients?

Ryan Dickerson, Jaideep Banerjee, Adam Rauckhorst, Douglas R. Pfeiffer, Gayle M. Gordillo, Savita Khanna, Kwame Osei and Sashwati Roy

Antioxidants & redox signaling, Vol.22(4), pp.339-345

02/01/2015

DOI: 10.1089/ars.2014.6138

PMCID: PMC4298154

PMID: 25268638

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Abstract

Fermented papaya preparation (FPP) is a nutritional supplement reported to act as an antioxidant by scavenging reactive oxygen species (ROS) and removing “bad ROS,” while inducing “respiratory burst” production of necessary “good ROS.” We sought to investigate the safety of oral administration of FPP (9 g/day, 6 weeks) to T2D patients with regard to its effect on the hyperglycemia status of these patients. Peripheral blood was collected during a baseline visit, followed by subsequent collections both during and after supplementation. Induced “respiratory burst” ROS production was measured at each visit in addition to fasting blood glucose, lipid profile, glycated hemoglobin (HbA1c), and lipid/protein peroxidation. Oral FPP supplementation induced “respiratory burst” in peripheral blood mononuclear cells while not influencing other blood parameters studied. When human monocytic THP-1 cells were supplemented with sugar-based FPP, cellular ATP and NADPH concentrations were increased while matched glucose alone did not produce similar effects, suggesting a glucose-independent component of FPP to be responsible for increasing cellular energetics. THP-1 cells supplemented with FPP also exhibited higher mitochondrial membrane potential (Δψm) and oxygen consumption as compared with cells treated with glucose alone. Taken together, our observations lead to the hypothesis that FPP corrects inducible “respiratory burst” function in type 2 diabetes patients. Antioxid. Redox Signal. 22, 339–345.

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Title: Subtitle: Does Oral Supplementation of a Fermented Papaya Preparation Correct Respiratory Burst Function of Innate Immune Cells in Type 2 Diabetes Mellitus Patients?
Creators: Ryan Dickerson - The Ohio State University Wexner Medical Center
Jaideep Banerjee - The Ohio State University Wexner Medical Center
Adam Rauckhorst - The Ohio State University Wexner Medical Center
Douglas R. Pfeiffer - The Ohio State University Wexner Medical Center
Gayle M. Gordillo - The Ohio State University Wexner Medical Center
Savita Khanna - The Ohio State University Wexner Medical Center
Kwame Osei - The Ohio State University Wexner Medical Center
Sashwati Roy - The Ohio State University Wexner Medical Center
Resource Type: Journal article
Publication Details: Antioxidants & redox signaling, Vol.22(4), pp.339-345
Publisher: Mary Ann Liebert, Inc
DOI: 10.1089/ars.2014.6138
PMID: 25268638
PMCID: PMC4298154
ISSN: 1523-0864
eISSN: 1557-7716
Language: English
Date published: 02/01/2015
Academic Unit: Molecular Physiology and Biophysics
Record Identifier: 9984446438602771

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