Does Peroxisome Proliferator-activated Receptor-γ (PPARγ) Protect from Hypertension Directly through Effects in the Vasculature?

Pimonrat Ketsawatsomkron; Christopher J Pelham; Séverine Groh; Henry L Keen; Frank M Faraci; Curt D Sigmund

doi:10.1074/jbc.R109.025031

Back

Does Peroxisome Proliferator-activated Receptor-γ (PPARγ) Protect from Hypertension Directly through Effects in the Vasculature?

Journal article

Open access

Peer reviewed

Does Peroxisome Proliferator-activated Receptor-γ (PPARγ) Protect from Hypertension Directly through Effects in the Vasculature?

Pimonrat Ketsawatsomkron, Christopher J Pelham, Séverine Groh, Henry L Keen, Frank M Faraci and Curt D Sigmund

The Journal of biological chemistry, Vol.285(13), pp.9311-9316

03/26/2010

DOI: 10.1074/jbc.R109.025031

PMCID: PMC2843178

PMID: 20129921

Files and links (1)

url

https://doi.org/10.1074/jbc.R109.025031View

Published (Version of record) Open Access

Abstract

Peroxisome proliferator-activated receptor-γ (PPARγ) is a ligand-activated transcription factor of the nuclear hormone receptor superfamily. Increasing evidence suggests that PPARγ is involved in the regulation of vascular function and blood pressure in addition to its well recognized role in metabolism. Thiazolidinediones, PPARγ agonists, lower blood pressure and have protective vascular effects through largely unknown mechanisms. In contrast, loss-of-function dominant-negative mutations in human PPARγ cause insulin resistance and severe early onset hypertension. Recent studies using genetically manipulated mouse models have begun to specifically address the importance of PPARγ in the vasculature. In this minireview, evidence for a protective role of PPARγ in the endothelium and vascular smooth muscle, derived largely from studies of genetically manipulated mice, will be discussed.

Hypertension

Molecular Bases of Disease

Arterial Pressure

PPAR

Minireviews

Transgenic

Transcription Factors

Gene Knockout

Smooth Muscle

Endothelium

Details

Title: Subtitle: Does Peroxisome Proliferator-activated Receptor-γ (PPARγ) Protect from Hypertension Directly through Effects in the Vasculature?
Creators: Pimonrat Ketsawatsomkron - From the Department of Internal Medicine, Center on Functional Genomics of Hypertension, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242
Christopher J Pelham - From the Department of Internal Medicine, Center on Functional Genomics of Hypertension, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242
Séverine Groh - From the Department of Internal Medicine, Center on Functional Genomics of Hypertension, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242
Henry L Keen - From the Department of Internal Medicine, Center on Functional Genomics of Hypertension, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242
Frank M Faraci - From the Department of Internal Medicine, Center on Functional Genomics of Hypertension, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242
Curt D Sigmund - From the Department of Internal Medicine, Center on Functional Genomics of Hypertension, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242
Resource Type: Journal article
Publication Details: The Journal of biological chemistry, Vol.285(13), pp.9311-9316
DOI: 10.1074/jbc.R109.025031
PMID: 20129921
PMCID: PMC2843178
NLM abbreviation: J Biol Chem
ISSN: 0021-9258
eISSN: 1083-351X
Publisher: American Society for Biochemistry and Molecular Biology; 9650 Rockville Pike, Bethesda, MD 20814, U.S.A
Language: English
Date published: 03/26/2010
Academic Unit: Molecular Physiology and Biophysics; Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine; Iowa Institute of Human Genetics
Record Identifier: 9984040583202771

Metrics

14 Record Views

57 Times Cited - Web of Science