Journal article
Does Pollen Trigger Urological Chronic Pelvic Pain Syndrome Flares? A Case-Crossover Analysis in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network
The Journal of urology, Vol.205(4), pp.1133-1138
04/01/2021
DOI: 10.1097/JU.0000000000001482
PMID: 33347771
Abstract
Purpose: We sought to determine whether pollen triggers urological chronic pelvic pain syndrome flares.
Materials and Methods: We assessed flare status every 2 weeks for 1 year as part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain case-crossover analysis of flare triggers (NCT01098279). Flare symptoms, flare start date and exposures in the 3 days before a flare were queried for the first 3 flares and at 3 randomly selected nonflare times. These data were linked to daily pollen count by date and the first 3 digits of participants' zip codes. Pollen count in the 3 days before and day of a flare, as well as pollen rises past established thresholds, were compared to nonflare values by conditional logistic regression. Poisson regression was used to estimate flare rates in the 3 weeks following pollen rises past established thresholds in the full longitudinal study. Analyses were performed in all participants and separately in those who reported allergies or respiratory tract disorders.
Results: Although no associations were observed for daily pollen count and flare onset, positive associations were observed for pollen count rises past medium or higher thresholds in participants with allergies or respiratory tract disorders in the case-crossover (OR 1.31, 95% CI 1.04-1.66) and full longitudinal (RR 1.23, 95% CI 1.03-1.46) samples.
Conclusions: We found some evidence to suggest that rising pollen count may trigger flares of urological chronic pelvic pain syndrome. If confirmed in future studies, these findings may help to inform flare pathophysiology, prevention and treatment, and control over the unpredictability of flares.
Details
- Title: Subtitle
- Does Pollen Trigger Urological Chronic Pelvic Pain Syndrome Flares? A Case-Crossover Analysis in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network
- Creators
- Irum Javed - Washington University in St. LouisTiange Yu - Washington University in St. LouisJieni Li - Washington University in St. LouisRatna Pakpahan - Washington University in St. LouisMelissa Milbrandt - Washington University in St. LouisGerald L. Andriole - Washington University in St. LouisJerry L. Lowder - Washington University in St. LouisH. Henry Lai - Washington University in St. LouisGraham A. Colditz - Washington University in St. LouisSiobhan Sutcliffe - Washington University in St. LouisMAPP Res Network
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.205(4), pp.1133-1138
- DOI
- 10.1097/JU.0000000000001482
- PMID
- 33347771
- NLM abbreviation
- J Urol
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Grant note
- U01DK082345; U01DK082325; U01DK082342; U01DK082344; U01DK082370; U01DK082315 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) U01 DK082315; U01 DK82316; U01 DK82325; U01 DK82333; U01 DK82342; U01 DK82344; U01 DK82345; U01 DK82370 / U.S. National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 04/01/2021
- Academic Unit
- Urology
- Record Identifier
- 9985244542902771
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