Journal article
Does Reduced Lung Diffusing Capacity for Carbon Monoxide Predict the Presence of Pulmonary Hypertension?
The American journal of the medical sciences, Vol.340(1), pp.54-59
2010
DOI: 10.1097/MAJ.0b013e3181dd1a89
PMID: 20463574
Abstract
Objective: The objective of this study was to determine whether reduced lung diffusing capacity for carbon monoxide (DLCO) predicts the presence of pulmonary hypertension (PH) in heterogeneous group of patients. Methods: Consecutive patients who underwent pulmonary function and transthoracic echocardiographic testing within a 6-month period were retrospectively identified by chart review. Right ventricular systolic pressure (RVSP) was measured using Doppler echocardiography. PH was defined as a RVSP >30 mm Hg. Patients were divided into 2 major groups: those whose RVSP was ≤30 mm Hg and those whose RVSP was >30 mm Hg. PH was classified as mild (RVSP = 31-40 mm Hg), moderate (RSVP = 41-60 mm Hg) and severe (RVSP >60 mm Hg). Results: A total of 398 patients were entered into the study: 264 (66.3%) with PH and 134 (33.7%) without PH. Patients with PH were older, had a lower mean percentage of predicted values for forced vital capacity (%FVC), for DLCO (%DLCO) and for DLCO corrected for alveolar volume (%DLCO/VA) than those without PH. Multivariate analysis identified age and %FVC as independent predictors of PH [odds ratios and 95% confidence intervals of 1.038 (1.020-1.056) and 0.972 (0.955-0.988), respectively]. There was a weak, but significant negative correlation between RVSP and %DLCO (r = -0.205, P = 0.001), but there was no correlation between RVSP and %DLCO/VA. Neither %DLCO nor %DLCO/VA was found to be independent predictors of PH. Conclusion: In a heterogeneous group of patients, %DLCO and %DLCO/VA do not independently predict the presence of PH. © 2010 Lippincott Williams & Wilkins.
Details
- Title: Subtitle
- Does Reduced Lung Diffusing Capacity for Carbon Monoxide Predict the Presence of Pulmonary Hypertension?
- Creators
- Kimberly S Delcour - University of MissouriAtul Singla - University of MissouriMohammad Jarbou - University of MissouriMartin Alpert - University of MissouriOusama Dabbagh - University of Missouri
- Resource Type
- Journal article
- Publication Details
- The American journal of the medical sciences, Vol.340(1), pp.54-59
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/MAJ.0b013e3181dd1a89
- PMID
- 20463574
- ISSN
- 0002-9629
- eISSN
- 1538-2990
- Language
- English
- Date published
- 2010
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984359783902771
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