Journal article
Does common cold coronavirus infection protect against severe SARS-CoV-2 disease?
The Journal of clinical investigation, Vol.131(1), e144807
01/04/2021
DOI: 10.1172/JCI144807
PMID: 33216734
Abstract
The coronavirus disease 2019 (COVID-19) pandemic continues to cause morbidity and mortality. Since SARS coronavirus 2 (SARS-CoV-2) was identified as the cause for COVID-19, some have questioned whether exposure to seasonal common cold coronaviruses (CCCs) could provide tangible protection against SARS-CoV-2 infection or disease. In this issue of the JCI, Sagar et al. examined SARS-CoV-2 infections and outcomes of patients who had previously tested positive or negative for CCC infection (CCC+ or CCC-) by a comprehensive respiratory panel using PCR. No differences were seen between groups in terms of susceptibility to SARS-CoV-2 infection. However, hospitalized patients with a documented history of CCC infection had lower rates of intensive care unit (ICU) admissions and higher rates of survival than hospitalized CCC- patients. While these findings are associative and not causative, they highlight evidence suggesting that previous CCC infection may influence the disease course of SARS-CoV-2 infection.
Details
- Title: Subtitle
- Does common cold coronavirus infection protect against severe SARS-CoV-2 disease?
- Creators
- David K Meyerholz - Department of PathologyStanley Perlman - Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.131(1), e144807
- Publisher
- American Society for Clinical Investigation
- DOI
- 10.1172/JCI144807
- PMID
- 33216734
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Language
- English
- Date published
- 01/04/2021
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Pathology; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9984070818502771
Metrics
15 Record Views