Does function follow form?: Methods to fuse structural and functional brain images show decreased linkage in schizophrenia

Andrew M Michael; Stefi A Baum; Tonya White; Oguz Demirci; Nancy C Andreasen; Judith M Segall; Rex E Jung; Godfrey Pearlson; Vince P Clark; Randy L Gollub; S. Charles Schulz; Joshua L Roffman; Kelvin O Lim; Beng-Choon Ho; H. Jeremy Bockholt; Vince D Calhoun

doi:10.1016/j.neuroimage.2009.08.056

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Does function follow form?: Methods to fuse structural and functional brain images show decreased linkage in schizophrenia

Journal article

Peer reviewed

Does function follow form?: Methods to fuse structural and functional brain images show decreased linkage in schizophrenia

Andrew M Michael, Stefi A Baum, Tonya White, Oguz Demirci, Nancy C Andreasen, Judith M Segall, Rex E Jung, Godfrey Pearlson, Vince P Clark, Randy L Gollub, …

NeuroImage (Orlando, Fla.), Vol.49(3), pp.2626-2637

02/01/2010

DOI: 10.1016/j.neuroimage.2009.08.056

PMCID: PMC2911118

PMID: 19733247

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https://www.ncbi.nlm.nih.gov/pmc/articles/2911118View

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Abstract

When both structural magnetic resonance imaging (sMRI) and functional MRI (fMRI) data are collected they are typically analyzed separately and the joint information is not examined. Techniques that examine joint information can help to find hidden traits in complex disorders such as schizophrenia. The brain is vastly interconnected, and local brain morphology may influence functional activity at distant regions. In this paper we introduce three methods to identify inter-correlations among sMRI and fMRI voxels within the whole brain. We apply these methods to examine sMRI gray matter data and fMRI data derived from an auditory sensorimotor task from a large study of schizophrenia. In Method 1 the sMRI–fMRI cross-correlation matrix is reduced to a histogram and results show that healthy controls (HC) have stronger correlations than do patients with schizophrenia (SZ). In Method 2 the spatial information of sMRI–fMRI correlations is retained. Structural regions in the cerebellum and frontal regions show more positive and more negative correlations, respectively, with functional regions in HC than in SZ. In Method 3 significant sMRI–fMRI inter-regional links are detected, with regions in the cerebellum showing more significant positive correlations with functional regions in HC relative to SZ. Results from all three methods indicate that the linkage between gray matter and functional activation is stronger in HC than SZ. The methods introduced can be easily extended to comprehensively correlate large data sets.

Schizophrenia

Data Fusion

Structural MRI

Functional MRI

Linkage

Cross-correlation

Details

Title: Subtitle: Does function follow form?: Methods to fuse structural and functional brain images show decreased linkage in schizophrenia
Creators: Andrew M Michael - The Mind Research Network, Albuquerque, NM 87106, USA
Stefi A Baum - Center for Imaging Science, Rochester Institute of Technology, Rochester, NY 14623, USA
Tonya White - Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA
Oguz Demirci - The Mind Research Network, Albuquerque, NM 87106, USA
Nancy C Andreasen - Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA
Judith M Segall - The Mind Research Network, Albuquerque, NM 87106, USA
Rex E Jung - The Mind Research Network, Albuquerque, NM 87106, USA
Godfrey Pearlson - Department of Psychiatry, Yale School of Medicine, New Haven, CT 06520, USA
Vince P Clark - The Mind Research Network, Albuquerque, NM 87106, USA
Randy L Gollub - Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
S. Charles Schulz - Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA
Joshua L Roffman - Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
Kelvin O Lim - Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA
Beng-Choon Ho - Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA
H. Jeremy Bockholt - The Mind Research Network, Albuquerque, NM 87106, USA
Vince D Calhoun - The Mind Research Network, Albuquerque, NM 87106, USA
Resource Type: Journal article
Publication Details: NeuroImage (Orlando, Fla.), Vol.49(3), pp.2626-2637
DOI: 10.1016/j.neuroimage.2009.08.056
PMID: 19733247
PMCID: PMC2911118
NLM abbreviation: Neuroimage
ISSN: 1053-8119
eISSN: 1095-9572
Publisher: Elsevier Inc
Language: English
Date published: 02/01/2010
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003420502771

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