Journal article
Does general anesthesia or intravitreal injection affect neurodevelopment in children undergoing ophthalmic procedures?
Current opinion in ophthalmology, Vol.30(5), pp.326-330
09/2019
DOI: 10.1097/ICU.0000000000000598
PMID: 31313750
Abstract
PURPOSE OF REVIEWTo review recent studies on potential neurodevelopmental impacts on the pediatric population through general anesthesia events or intravitreal anti-vascular endothelial growth factor (VEGF) injection.
RECENT FINDINGSStudies on this topic have been extensive with varied reported neurodevelopmental outcomes. Initial investigations in rodents and primates showed negative impact of anesthetics on neurodevelopment. Subsequent retrospective human reviews had mixed results whereas more recent sibling and prospective studies have been published without evidence of clinically significant impact. A similar narrative has more recently come to play regarding the long-term effects of intravitreal injections used in neonates with retinopathy of prematurity. Publications initially indicated a negative correlation whereas later reviews have found no difference between those receiving injections versus laser treatment.
SUMMARYGiven that recent data on both general anesthesia events and intravitreal anti-VEGF injections do not show a long-term negative neurodevelopmental impact, ocular procedures needed to improve a pediatric patientʼs vision or quality of life should not be delayed.
Details
- Title: Subtitle
- Does general anesthesia or intravitreal injection affect neurodevelopment in children undergoing ophthalmic procedures?
- Creators
- Lindsay De Andrade - Stein Eye Institute, University of California, Los Angeles, California, USASherwin Isenberg
- Resource Type
- Journal article
- Publication Details
- Current opinion in ophthalmology, Vol.30(5), pp.326-330
- DOI
- 10.1097/ICU.0000000000000598
- PMID
- 31313750
- ISSN
- 1040-8738
- eISSN
- 1531-7021
- Language
- English
- Date published
- 09/2019
- Academic Unit
- Stead Family Department of Pediatrics; Ophthalmology and Visual Sciences
- Record Identifier
- 9984111191302771
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