Journal article
Does leptin cause functional peripheral sympatholysis?
American journal of hypertension, Vol.14(7), pp.615-618
07/2001
DOI: 10.1016/S0895-7061(01)01287-0
PMID: 11465643
Abstract
Leptin is a protein produced by adipocytes. Leptin is known to markedly and rapidly increase sympathetic nerve activity to the kidney and hindlimb of experimental animals. Recent studies suggest that leptin may stimulate endothelial production of nitric oxide, which could oppose sympathetically induced vasoconstriction. We tested the hypothesis that such actions of leptin may produce peripheral functional sympatholysis. In Sprague-Dawley rats, we intermittently stimulated the abdominal sympathetic trunk and measured renal and hindlimb blood flows before and after 3 h of infusion of leptin (1000 μg/kg, n = 7) or vehicle (n = 7). Leptin did not change arterial pressure, heart rate, or renal or hindlimb conductance over the course of 3 h. In addition, leptin did not significantly alter sympathetically mediated vasomotor responses to electrical stimulation, as compared with vehicle. Thus, we conclude that leptin does not change regional blood flows, and that leptin also does not appear to have vascular or neural actions to cause peripheral functional sympatholysis. Am J Hypertens 2001;14:615–618 © 2001 American Journal of Hypertension, Ltd.
Details
- Title: Subtitle
- Does leptin cause functional peripheral sympatholysis?
- Creators
- Ali Jalali - Hypertension Genetics Specialized Center of Research, Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa, USADonald A Morgan - Hypertension Genetics Specialized Center of Research, Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa, USAWilliam I Sivitz - Hypertension Genetics Specialized Center of Research, Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa, USAMarcelo L.G Correia - Hypertension Genetics Specialized Center of Research, Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa, USAAllyn L Mark - Hypertension Genetics Specialized Center of Research, Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa, USAWilliam G Haynes - Hypertension Genetics Specialized Center of Research, Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- American journal of hypertension, Vol.14(7), pp.615-618
- Publisher
- Oxford University Press
- DOI
- 10.1016/S0895-7061(01)01287-0
- PMID
- 11465643
- ISSN
- 0895-7061
- eISSN
- 1879-1905
- Language
- English
- Date published
- 07/2001
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094620002771
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