Does loop electrosurgical excision procedure of the uterine cervix affect anti-Müllerian hormone levels?

Martha M Sklavos; Cassandra N Spracklen; Audrey F Saftlas; Ligia A Pinto

doi:10.1155/2014/875438

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Does loop electrosurgical excision procedure of the uterine cervix affect anti-Müllerian hormone levels?

Journal article

Open access

Peer reviewed

Does loop electrosurgical excision procedure of the uterine cervix affect anti-Müllerian hormone levels?

Martha M Sklavos, Cassandra N Spracklen, Audrey F Saftlas and Ligia A Pinto

BioMed research international, Vol.2014, 875438

2014

DOI: 10.1155/2014/875438

PMCID: PMC3953513

PMID: 24707500

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https://doi.org/10.1155/2014/875438View

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Abstract

A delayed time to pregnancy was recently reported for women who had a loop electrosurgical excision procedure (LEEP) to remove cervical intraepithelial neoplasia (CIN) grade 2 or 3. The objective of the current study was to determine if treatment of CIN with LEEP is associated with decreased levels of anti-Müllerian hormone (AMH), a marker of ovarian reserve. AMH levels were measured in 18 women treated with LEEP and 18 age-matched controls, who had colposcopy only and did not require LEEP. Cases and controls had their blood drawn at study entry time zero and again 6 months later. The mean AMH level decreased significantly from baseline to follow-up; however, no significant differences were observed when stratifying by LEEP status, suggesting that both groups experienced a similar decrease in AMH levels during the follow-up period. Although women treated with LEEP had lower overall AMH levels than controls at both baseline and follow-up, these differences were not statistically significant. Overall, the delayed time to pregnancy observed in women treated with LEEP is likely not due to a LEEP-associated decrease in ovarian reserve as measured by AMH; thus, other mechanism are responsible for the delayed time to pregnancy associated with LEEP.

Pregnancy

Anti-Mullerian Hormone - biosynthesis

Anti-Mullerian Hormone - secretion

Cervical Intraepithelial Neoplasia - pathology

Cervical Intraepithelial Neoplasia - secretion

Cervical Intraepithelial Neoplasia - surgery

Cervix Uteri - pathology

Cervix Uteri - secretion

Cervix Uteri - surgery

Electrosurgery - adverse effects

Female

Humans

Details

Title: Subtitle: Does loop electrosurgical excision procedure of the uterine cervix affect anti-Müllerian hormone levels?
Creators: Martha M Sklavos - Frederick National Laboratory for Cancer Research
Cassandra N Spracklen - University of Iowa
Audrey F Saftlas - University of Iowa
Ligia A Pinto - Frederick National Laboratory for Cancer Research
Resource Type: Journal article
Publication Details: BioMed research international, Vol.2014, 875438
DOI: 10.1155/2014/875438
PMID: 24707500
PMCID: PMC3953513
NLM abbreviation: Biomed Res Int
ISSN: 2314-6133
eISSN: 2314-6141
Grant note: HHSN261200800001E / PHS HHS HHSN261200800001C / CCR NIH HHS HHSN261200800001E / NCI NIH HHS 5R21A1068111-02 / PHS HHS
Language: English
Date published: 2014
Academic Unit: Epidemiology
Record Identifier: 9984364430102771

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