Journal article
Does prophylactic administration of corticosteroid reduce the risk and severity of post-ERCP pancreatitis: a randomized, prospective, multicenter study
Gastrointestinal endoscopy, Vol.58(1), pp.23-29
2003
DOI: 10.1067/mge.2003.307
PMID: 12838216
Abstract
Background: Pancreatitis is the most common major complication of diagnostic and therapeutic ERCP. There have been continuing efforts to identify a pharmacologic agent capable of reducing the frequency and severity of this complication. On the basis of several case reports, experimental data, and knowledge of their mechanism of action, corticosteroids might be effective in this regard. The aim of this randomized, double-blind, controlled trial was to determine whether prophylactic, orally administered corticosteroid reduces the frequency and/or severity of post-ERCP pancreatitis.
Methods: A total of 1115 patients were randomized to receive either prednisone (40 mg) or a placebo orally 15 hours and 3 hours before ERCP. A 160 variable database was prospectively collected according to a defined protocol on patients undergoing diagnostic or therapeutic ERCP at 15 centers in the Midwest Pancreaticobiliary Group. Standardized criteria were used to diagnose and grade the severity of postprocedure pancreatitis.
Results: The overall frequency of pancreatitis was 15.07%. It occurred in 92 of 555 patients in the corticosteroid group (16.6%), and in 76 of 560 patients in the control group (13.6%; p = 0.19). The pancreatitis was mild in 10.04%, moderate in 4.04%, and severe in 0.99%. There was no difference between the groups with regard to the severity of pancreatitis. Moreover, the groups were similar with regard to age, gender, body mass index, frequency of prior pancreatitis, type of procedure performed (diagnostic or therapeutic), difficulty of cannulation, frequency of pre-cut sphincterotomy, pancreatic sphincterotomy, sphincter of Oddi dysfunction, sphincter of Oddi manometry, pancreatic acinarization, chronic pancreatitis, number of pancreatic duct injections, and bile duct diameter.
Conclusion: Prophylactic orally administered corticosteroid did not reduce the frequency or severity of post-ERCP pancreatitis.
Details
- Title: Subtitle
- Does prophylactic administration of corticosteroid reduce the risk and severity of post-ERCP pancreatitis: a randomized, prospective, multicenter study
- Creators
- Stuart SHERMAN - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesUrszula BLAUT - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesWilliam B SILVERMAN - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesKulwinder S DUA - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesGiuseppe ALIPERTI - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesPaul YAKSHE - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesMichael UZER - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesWhitney JONES - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesJohn GOFF - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesDee EARLE - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesM'Hamed TEMKIT - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesGlen A LEHMAN - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesJames L WATKINS - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesJeffrey BARNETT - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesMartin FREEMAN - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesJoseph GEENEN - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesMichael RYAN - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesHarrison PARKER - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesJames T FRAKES - GI Consultants Ltd., Milwaukee, Wisconsin, United StatesEvan L FOGEL - GI Consultants Ltd., Milwaukee, Wisconsin, United States
- Resource Type
- Journal article
- Publication Details
- Gastrointestinal endoscopy, Vol.58(1), pp.23-29
- Publisher
- Elsevier
- DOI
- 10.1067/mge.2003.307
- PMID
- 12838216
- ISSN
- 0016-5107
- eISSN
- 1097-6779
- Language
- English
- Date published
- 2003
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984094774602771
Metrics
14 Record Views