Does surgery or radiation provide the best overall survival in Ewing's sarcoma? A review of the National Cancer Data Base

Benjamin J Miller; Yubo Gao; Kyle R Duchman

doi:10.1002/jso.24652

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Does surgery or radiation provide the best overall survival in Ewing's sarcoma? A review of the National Cancer Data Base

Journal article

Peer reviewed

Does surgery or radiation provide the best overall survival in Ewing's sarcoma? A review of the National Cancer Data Base

Benjamin J Miller, Yubo Gao and Kyle R Duchman

Journal of surgical oncology, Vol.116(3), pp.384-390

09/2017

DOI: 10.1002/jso.24652

PMID: 28420037

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Abstract

There is continuing debate regarding the ideal modality for local control of the primary tumor for patients with Ewing's sarcoma. The primary aim of this study is to investigate the impact of the method of local control on overall survival in patients with Ewing's sarcoma. The National Cancer Data Base was used to identify patients <40 years of age with high-grade Ewing's sarcoma of bone. A Kaplan-Meier survival analysis was performed at 2, 5, and 10 years. Factors with a level of significance of P < 0.1 at the 5-year time point were included in a multivariate Cox proportional hazards model. Diminished 5-year survival was noted for patients with metastatic disease, local control with radiation alone, age ≥18 years, tumor size >8 cm, and male sex while controlling for tumor site. Surgery alone was consistently the method of local control that resulted in the highest overall survival. Surgery alone resulted in the best overall survival for patients with Ewing's sarcoma of bone. The results of this investigation provide support to the approach of surgical resection with negative margins when possible.

Bone Neoplasms - mortality

United States - epidemiology

Humans

Kaplan-Meier Estimate

Proportional Hazards Models

Child, Preschool

Infant

Male

Survival Rate

Sarcoma, Ewing - mortality

Bone Neoplasms - surgery

Socioeconomic Factors

Young Adult

Bone Neoplasms - radiotherapy

Adolescent

Adult

Female

Child

Infant, Newborn

Sarcoma, Ewing - radiotherapy

Databases, Factual

Sarcoma, Ewing - surgery

Details

Title: Subtitle: Does surgery or radiation provide the best overall survival in Ewing's sarcoma? A review of the National Cancer Data Base
Creators: Benjamin J Miller - Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Yubo Gao - Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Kyle R Duchman - Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Journal of surgical oncology, Vol.116(3), pp.384-390
Publisher: United States
DOI: 10.1002/jso.24652
PMID: 28420037
ISSN: 0022-4790
eISSN: 1096-9098
Grant note: P30 CA086862 / NCI NIH HHS
Language: English
Date published: 09/2017
Academic Unit: Orthopedics and Rehabilitation; Internal Medicine
Record Identifier: 9984040389302771

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41 Times Cited - Web of Science