Does the intensity of daily walking matter for protecting against the development of a slow gait speed in people with or at high risk of knee osteoarthritis? An observational study

S.A.M Fenton; T Neogi; D Dunlop; M Nevitt; M Doherty; J.L Duda; R Klocke; A Abhishek; A Rushton; W Zhang; C.E Lewis; J Torner; G Kitas; D.K White; the Multicenter Osteoarthritis Group

doi:10.1016/j.joca.2018.04.015

Back

Does the intensity of daily walking matter for protecting against the development of a slow gait speed in people with or at high risk of knee osteoarthritis? An observational study

Journal article

Open access

Peer reviewed

Does the intensity of daily walking matter for protecting against the development of a slow gait speed in people with or at high risk of knee osteoarthritis? An observational study

S.A.M Fenton, T Neogi, D Dunlop, M Nevitt, M Doherty, J.L Duda, R Klocke, A Abhishek, A Rushton, W Zhang, …

Osteoarthritis and cartilage, Vol.26(9), pp.1181-1189

09/2018

DOI: 10.1016/j.joca.2018.04.015

PMCID: PMC6098720

PMID: 29729332

Files and links (1)

url

https://doi.org/10.1016/j.joca.2018.04.015View

Published (Version of record) Open Access

Abstract

Knee osteoarthritis (OA) is a risk factor for a decline in gait speed. Daily walking reduces the risk of developing slow gait speed and future persistent functional limitation. However, the protective role of walking intensity is unclear. We investigated the association of substituting time spent not walking, with walking at light and moderate-to-vigorous intensities for incident slow gait over 2-years, among people with or at high risk of knee OA. We used baseline and 2-year follow-up data from the Multicenter Osteoarthritis (MOST) study (n = 1731) and the Osteoarthritis Initiative (OAI, n = 1925). Daily walking intensity was objectively assessed using accelerometer-enabled devices, and classified as; not walking (<1 steps/min), very-light (1–49 steps/min), light (50–100 steps/min), and moderate-to-vigorous (>100 steps/min). We defined slow gait during a 20-m walk, as <1 m/s and <1.2 m/s. Isotemporal substitution evaluated time-substitution effects on incident slow gait outcomes at 2-years. Replacing 20 min/day of not walking with walking at a moderate-to-vigorous intensity, demonstrated small to moderate reductions in the risk of developing a gait speed <1.0 m/s (Relative Risk [95% confidence interval (CI)]; MOST = 0.51 [0.27, 0.98], OAI = 0.21 [0.04, 0.98]), and <1.2 m/s (MOST = 0.73 [0.53, 1.00], OAI = 0.65 [0.36, 1.18]). However, only risk reductions for <1.0 m/s met statistical significance. Replacing not walking with very-light or light intensity walking was not associated with the risk of developing slow gait outcomes. When possible, walking at a moderate-to-vigorous intensity (>100 steps/min) may be best recommended in order to reduce the risk of developing critical slow gait speed among people with, or at high risk of knee OA.

Walking

Gait speed

Isotemporal substitution

Knee osteoarthritis

Physical function

Accelerometry

Details

Title: Subtitle: Does the intensity of daily walking matter for protecting against the development of a slow gait speed in people with or at high risk of knee osteoarthritis? An observational study
Creators: S.A.M Fenton - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, England, UK
T Neogi - Clinical Epidemiology Research and Training Unit, Boston University Medical Center, Boston, MA, USA
D Dunlop - Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
M Nevitt - University of California San Francisco, San Francisco, CA, USA
M Doherty - Faculty of Medicine and Health Sciences, University of Nottingham, England, UK
J.L Duda - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, England, UK
R Klocke - Department of Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, England, UK
A Abhishek - Faculty of Medicine and Health Sciences, University of Nottingham, England, UK
A Rushton - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, England, UK
W Zhang - University of Nottingham
C.E Lewis - University of Alabama at Birmingham, Birmingham, AL, USA
J Torner - University of Iowa, Iowa City, IA, USA
G Kitas - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, England, UK
D.K White - Department of Physical Therapy, University of Delaware, Newark, DE, USA
the Multicenter Osteoarthritis Group
Resource Type: Journal article
Publication Details: Osteoarthritis and cartilage, Vol.26(9), pp.1181-1189
DOI: 10.1016/j.joca.2018.04.015
PMID: 29729332
PMCID: PMC6098720
NLM abbreviation: Osteoarthritis Cartilage
ISSN: 1063-4584
eISSN: 1522-9653
Publisher: Elsevier Ltd
Language: English
Date published: 09/2018
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995178202771

Metrics

38 Record Views

20 Times Cited - Web of Science