Journal article
Does the probiotic L. casei help prevent recurrence after transurethral resection for superficial bladder cancer?
Nature clinical practice urology, Vol.5(10), pp.526-527
10/2008
DOI: 10.1038/ncpuro1199
PMID: 18728629
Abstract
A randomized clinical trial conducted in Japan compared standard intravesical epirubicin alone with epirubicin plus 1 year of oral Lactobacillus casei strain Shirota in patients who had undergone resection of intermediate-risk, non-muscle-invasive bladder cancer. A statistically significant ∼15% absolute reduction in long-term tumor recurrence was seen in the group that received the oral probiotic; however, as the dropout rate was nearly 3.5-fold greater in the probiotic group, and as neither the treating doctors nor their patients were blinded to the assigned treatment, uncertainty remains as to the reliability of the findings. Also unknown is whether other probiotics would provide similar results and whether these agents would provide benefits in conjunction with other intravesical chemotherapeutic drugs. At this time, while physicians should not necessarily promote the use of probiotics, neither should they discourage their patients from trying what could amount to a much-needed boost to the efficacy of conventional intravesical chemotherapy.
Details
- Title: Subtitle
- Does the probiotic L. casei help prevent recurrence after transurethral resection for superficial bladder cancer?
- Creators
- Michael A O'Donnell - Department of Urology, University of Iowa, Iowa City, IA 52242-1089, USA. michael-odonnell@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Nature clinical practice urology, Vol.5(10), pp.526-527
- DOI
- 10.1038/ncpuro1199
- PMID
- 18728629
- ISSN
- 1743-4270
- eISSN
- 1743-4289
- Language
- English
- Date published
- 10/2008
- Academic Unit
- Urology
- Record Identifier
- 9984320856702771
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