Does the relationship between prenatal care and birth weight vary by oral clefts? evidence using South American and United States samples

Kwame A Nyarko; Jorge Lopez-Camelo; Eduardo E Castilla; George L Wehby

doi:10.1016/j.jpeds.2012.06.040

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Does the relationship between prenatal care and birth weight vary by oral clefts? evidence using South American and United States samples

Journal article

Open access

Peer reviewed

Does the relationship between prenatal care and birth weight vary by oral clefts? evidence using South American and United States samples

Kwame A Nyarko, Jorge Lopez-Camelo, Eduardo E Castilla and George L Wehby

The Journal of pediatrics, Vol.162(1), pp.42-49.e1

01/2013

DOI: 10.1016/j.jpeds.2012.06.040

PMCID: PMC3485451

PMID: 22835882

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Abstract

To evaluate if the association between prenatal care use and birth weight (BW) varies for infants with cleft lip and/or cleft palate (CL/P), classified into isolated and non-isolated forms, compared with unaffected infants. The study employed 2 datasets. The first included a multi-country sample of 2405 infants with CL/P and 24046 infants without CL/P born in 1996-2007 in South America. The second was a sample of 2122 infants with CL/P and 297415 without CL/P from the United States 2004 natality dataset. Separate analyses were performed for the South American and United States samples. The association between prenatal care and BW was evaluated separately for isolated CL/P, non-isolated CL/P, and unaffected infants using regression models adjusting for several background characteristics. Prenatal care was associated with improved BW for all infant groups, with greater BW increases for infants with CL/P particularly non-isolated forms. In the South American sample, BW increased by 108, 69, and 40 g on average per prenatal visit for infants with non-isolated CL/P, infants with isolated CL/P, and unaffected infants, respectively. In the United States sample, BW increased by 51, 21, and 16 g on average per prenatal visit for these infant groups, respectively. Prenatal care was associated with larger BW increases for pregnancies complicated with CL/P, particularly non-isolated forms, compared with unaffected pregnancies. Given that reduced BW is a well-recognized comorbidity of CL/P, the findings highlight the importance of prenatal care for at-risk pregnancies as a tertiary-prevention intervention to reduce the health burden of CL/P.

Pregnancy

Birth Weight

United States - epidemiology

South America - epidemiology

Cleft Lip - epidemiology

Humans

Prenatal Care - utilization

Female

Male

Cleft Palate - epidemiology

Infant, Newborn

Details

Title: Subtitle: Does the relationship between prenatal care and birth weight vary by oral clefts? evidence using South American and United States samples
Creators: Kwame A Nyarko - Department of Health Management and Policy, University of Iowa, Iowa City, IA, USA
Jorge Lopez-Camelo
Eduardo E Castilla
George L Wehby
Resource Type: Journal article
Publication Details: The Journal of pediatrics, Vol.162(1), pp.42-49.e1
Publisher: United States
DOI: 10.1016/j.jpeds.2012.06.040
PMID: 22835882
PMCID: PMC3485451
ISSN: 0022-3476
eISSN: 1097-6833
Grant note: 1R03 DE018394 / NIDCR NIH HHS R03 DE018394 / NIDCR NIH HHS
Language: English
Date published: 01/2013
Academic Unit: Preventive and Community Dentistry; Health Management and Policy; Economics; Public Policy Center (Archive)
Record Identifier: 9984063142602771

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