Does the type of anesthetic agent affect remifentanil effect-site concentration for preventing endotracheal tube-induced cough during anesthetic emergence? Comparison of propofol, sevoflurane, and desflurane

Jae Hoon Lee; Seung Ho Choi; Yong Seon Choi; Bahn Lee; Shi Joon Yang; Jeong-Rim Lee

doi:10.1016/j.jclinane.2014.02.002

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Does the type of anesthetic agent affect remifentanil effect-site concentration for preventing endotracheal tube-induced cough during anesthetic emergence? Comparison of propofol, sevoflurane, and desflurane

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Does the type of anesthetic agent affect remifentanil effect-site concentration for preventing endotracheal tube-induced cough during anesthetic emergence? Comparison of propofol, sevoflurane, and desflurane

Jae Hoon Lee, Seung Ho Choi, Yong Seon Choi, Bahn Lee, Shi Joon Yang and Jeong-Rim Lee

Journal of clinical anesthesia, Vol.26(6), pp.466-474

09/01/2014

DOI: 10.1016/j.jclinane.2014.02.002

PMID: 25200640

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https://ir.ymlib.yonsei.ac.kr/handle/22282913/99894View

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Abstract

Study Objective: To investigate whether the type of anesthetic agent administered affects the antitussive effect of remifentanil. Design: Prospective randomized study. Setting: Operating room of a university hospital. Patients: 78 ASA physical status 1 and 2 women, aged 20 to 65 years, who were scheduled to undergo a thyroidectomy. Interventions: Patients were randomly assigned to three groups to receive anesthesia with propofol (Group P), sevoflurane (Group S), or desflurane (Group D). The main anesthetics were titrated to maintain a target Bispectral Index for hypnosis of 40 to 60. Remifentanil was administered via effect-site target-controlled infusion (TCI). To determine the effective remifentanil effect-site concentration (Ce) to suppress coughing in each group, the up-and-down sequential allocation design was used. Measurements: The half maximal effective concentration (EC50) values of remifentanil for preventing coughing in the groups were estimated using isotonic regression and compared among the groups. Main Results: The EC50 of remifentanil for cough suppression in Group P [1.60 ng/mL (98.3% CI, 0.92 - 1.75 ng/mL)] was statistically lower than in Group D [1.96 ng/mL (98.3% CI, 1.81 - 2.50 ng/mL)]. The EC50 in Group S was 1.75 ng/mL (98.3% CI, 1.39 - 2.13 ng/mL), which was higher than in Group P and lower than in Group D, but did not differ significantly from either group. Conclusions: Remifentanil administration for cough suppression during emergence should be customized to the anesthetic agent. (C) 2014 Elsevier Inc. All rights reserved.

Anesthesiology

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Title: Subtitle: Does the type of anesthetic agent affect remifentanil effect-site concentration for preventing endotracheal tube-induced cough during anesthetic emergence? Comparison of propofol, sevoflurane, and desflurane
Creators: Jae Hoon Lee - Yonsei University
Seung Ho Choi - Yonsei University
Yong Seon Choi - Yonsei University
Bahn Lee - Yonsei University
Shi Joon Yang - Yonsei University
Jeong-Rim Lee - Yonsei University
Resource Type: Journal article
Publication Details: Journal of clinical anesthesia, Vol.26(6), pp.466-474
DOI: 10.1016/j.jclinane.2014.02.002
PMID: 25200640
NLM abbreviation: J Clin Anesth
ISSN: 0952-8180
eISSN: 1873-4529
Publisher: Elsevier
Number of pages: 9
Language: English
Date published: 09/01/2014
Academic Unit: Anesthesia
Record Identifier: 9984806613702771

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