Journal article
Domesticated transposable element gene products in human cancer
Mobile genetic elements, Vol.3(5), pp.e26693-e26693
09/01/2013
DOI: 10.4161/mge.26693
PMCID: PMC3827096
PMID: 24251072
Abstract
The adaptation of transposable elements inserted within the genome to serve novel functions in a host cell, a process known as molecular domestication, is a widespread phenomenon in nature. Around fifty protein-coding genes in humans have arisen through this mechanism. Functional characterization of these domesticated genes has revealed involvement in a multitude of diverse cellular processes. Some of these functions are related to cellular activities and pathways known to be involved in cancer development. In this mini-review we discuss such roles of domesticated genes that may be aberrantly regulated in human cancer, as well as studies that have identified disrupted expression in tumors. We also describe studies that have provided definitive experimental evidence for transposable element-derived gene products in promoting tumorigenesis.
Details
- Title: Subtitle
- Domesticated transposable element gene products in human cancer
- Creators
- Jesse D Riordan - Department of Anatomy & Cell Biology; Roy J. & Lucille A. Carver College of Medicine; University of Iowa; Iowa City, IA USAAdam J Dupuy
- Resource Type
- Journal article
- Publication Details
- Mobile genetic elements, Vol.3(5), pp.e26693-e26693
- Publisher
- United States
- DOI
- 10.4161/mge.26693
- PMID
- 24251072
- PMCID
- PMC3827096
- ISSN
- 2159-2543
- eISSN
- 2159-256X
- Language
- English
- Date published
- 09/01/2013
- Academic Unit
- Anatomy and Cell Biology; Pathology
- Record Identifier
- 9984025312902771
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