Journal article
Dominant nature of the resistance to Fas- and tumor necrosis factor-alpha-mediated apoptosis in human prostatic carcinoma cell lines
Cancer research (Chicago, Ill.), Vol.57(18), pp.3941-3943
09/15/1997
PMID: 9307276
Abstract
We have recently found (O. W. Rokhlin et al., Cancer Res., 57: 1758-1768, 1997) that, although Fas ligation induced apoptosis in two of six human prostatic carcinoma cell lines investigated, the apoptotic machinery involved in Fas-mediated killing is already in place in Fas-resistant cell lines. Here, we investigated Fas- and tumor necrosis factor-alpha (TNF-alpha)-mediated apoptosis in cell hybrids between resistant (DU145 and JCA1) and sensitive (ALVA31 and PC3) cell lines. All three types of hybrid cells investigated, F1(DU145 x PC3), F1(JCA1 x PC3), and F1(JCA1 x ALVA31), were found to be resistant to Fas- and TNF-alpha-mediated apoptosis at the same level as the corresponding parental resistant cell lines. These results indicate that resistance to Fas- and TNF-alpha-mediated apoptosis dominates over sensitivity in cell hybrids and suggest that resistance may be regulated by an apoptosis suppressor factor or factors acting in resistant but not in sensitive cells.
Details
- Title: Subtitle
- Dominant nature of the resistance to Fas- and tumor necrosis factor-alpha-mediated apoptosis in human prostatic carcinoma cell lines
- Creators
- O W Rokhlin - Department of Pathology, University of Iowa, Iowa City 52242, USAB S HostagerG A BishopS P SidorenkoR A GloverA V GudkovM B Cohen
- Resource Type
- Journal article
- Publication Details
- Cancer research (Chicago, Ill.), Vol.57(18), pp.3941-3943
- Publisher
- United States
- PMID
- 9307276
- ISSN
- 0008-5472
- eISSN
- 1538-7445
- Grant note
- A128847 / PHS HHS CA66570 / NCI NIH HHS T32AI07260 / NIAID NIH HHS
- Language
- English
- Date published
- 09/15/1997
- Academic Unit
- Microbiology and Immunology; President; Pathology; Biology
- Record Identifier
- 9984002382502771
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