Journal article
Domperidone elevates rat plasma β-endorphin-immunoreactivity when administered peripherally but not intracerebroventricularly
Life sciences (1973), Vol.31(10), pp.981-985
1982
DOI: 10.1016/0024-3205(82)90169-2
PMID: 6290812
Abstract
Domperidone, a dopamine receptor antagonist which apparently does not penetrate the blood-brain barrier in rats was administered to adult males. Domperidone 500 μg and 100μg, given through intracarotid cannula, significantly elevated plasma β-endorphin- immunoreactivity (β-EP-I) at +15 min. To show that only a peripheral site(s) of action is implicated, domperidone was given to rats by cannulae implanted into both lateral ventricles. Plasma β-EP-I was unaffected by this route of administration. These results suggest that plasma β-EP-I is tonically inhibited by dopamine acting at site(s) outside of the blood-brain barrier.
Details
- Title: Subtitle
- Domperidone elevates rat plasma β-endorphin-immunoreactivity when administered peripherally but not intracerebroventricularly
- Creators
- B. Sharp - United States Department of Veterans AffairsB. Kasson - UCLA HealthD. Marshak - United States Department of Veterans AffairsR. Ross - United States Department of Veterans AffairsR. George - United States Department of Veterans AffairsJ. Sowers - United States Department of Veterans AffairsT. Yamada - UCLA Health
- Resource Type
- Journal article
- Publication Details
- Life sciences (1973), Vol.31(10), pp.981-985
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0024-3205(82)90169-2
- PMID
- 6290812
- ISSN
- 0024-3205
- eISSN
- 1879-0631
- Language
- English
- Date published
- 1982
- Academic Unit
- Neuroscience and Pharmacology
- Record Identifier
- 9984303853302771
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