Journal article
Donepezil Effects on Cerebral Blood Flow in Older Adults With Mild Cognitive Deficits
The journal of neuropsychiatry and clinical neurosciences, Vol.18(2), pp.178-185
04/2006
DOI: 10.1176/jnp.2006.18.2.178
PMID: 16720794
Abstract
Cerebral blood flow (CBF) was assessed during a verbal recall task using [(15)O]water positron emission tomography (PET) in older adults with mild cognitive deficits participating in a placebo-controlled donepezil trial. The placebo group demonstrated reduced CBF in the left frontal and temporal regions over the 6-month period, while those receiving donepezil did not. The placebo group's performance did not change on a list-learning task, while the donepezil group's performance improved, despite having had lower performance at intake. These findings suggest that donepezil treatment may be associated with a relative maintenance of CBF and improved list-learning.
Details
- Title: Subtitle
- Donepezil Effects on Cerebral Blood Flow in Older Adults With Mild Cognitive Deficits
- Creators
- Xiying ChenVincent A MagnottaKevin DuffLaura L Boles PontoSusan K Schultz
- Resource Type
- Journal article
- Publication Details
- The journal of neuropsychiatry and clinical neurosciences, Vol.18(2), pp.178-185
- Publisher
- American Psychiatric Publishing, Inc
- DOI
- 10.1176/jnp.2006.18.2.178
- PMID
- 16720794
- ISSN
- 0895-0172
- eISSN
- 1545-7222
- Language
- English
- Date published
- 04/2006
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984051571702771
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