Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

Michal Pazdernik; Helena Bedanova; Zhi Chen; Josef Kautzner; Vojtech Melenovsky; Ivan Malek; Antonij Slavcev; Michaela Bartonova; Vladimir Karmazin; Tomas Eckhardt; Ales Tomasek; Eva Ozabalova; Tomas Kovarnik; Peter Wohlfahrt; Milan Sonka

doi:10.1016/j.trim.2020.101340

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Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

Journal article

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Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

Michal Pazdernik, Helena Bedanova, Zhi Chen, Josef Kautzner, Vojtech Melenovsky, Ivan Malek, Antonij Slavcev, Michaela Bartonova, Vladimir Karmazin, Tomas Eckhardt, …

Transplant immunology, Vol.65, pp.101340-101340

04/2021

DOI: 10.1016/j.trim.2020.101340

PMID: 33069814

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https://www.ncbi.nlm.nih.gov/pmc/articles/9114443View

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Abstract

Recent studies suggested potential positive correlations between HLA-specific antibodies and development of cardiac allograft vasculopathy (CAV). This prospective two-center study investigated early progression of CAV by coronary optical coherence tomography in 1 month and 12 months after heart transplantation (HTx) in 104 patients. Detection and characterization of donor specific (DSA) and MHC class-I polypeptide-related sequence A (MICA) antibodies were performed before, 1, 6 and 12 months after transplantation. During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area (P < .001), and progression in mean intimal thickness (IT) (P < .001). DSA and anti-MICA occurred in 17% of all patients, but no significant relationship was observed between presence of DSA/anti-MICA and IT progression within 12 months after HTx. In contrast, we observed significant association between presence of DSA (p=0.031), de-novo DSA (p=0.031), HLA Class II DSA (p=0.017) and media thickness (MT) progression. Results of our study did not identify a direct association between presence of DSA/anti-MICA and intimal thickness progression in an early period after HTx. However, we found significant relationships between DSA and media thickness progression that may identify a newly recognized immune-pathological aspect of CAV. •We observed significant luminal area reduction, and intimal thickness progression within the first post-transplant year.•DSA, de-novo DSA and HLA Class II DSA presence were significantly associated with media thickness progression.•DSA and anti-MICA presence was not related to intimal thickness progression within the first post HTx year.

Heart transplant

Intimal thickness

Donor specific antibodies

Cardiac allograft vasculopathy

Details

Title: Subtitle: Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis
Creators: Michal Pazdernik - Department of Cardiology, IKEM, Prague, Czech Republic
Helena Bedanova - Cardiovascular and Transplantation Surgery, Brno, Czech Republic
Zhi Chen - Iowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, IA, USA
Josef Kautzner - Department of Cardiology, IKEM, Prague, Czech Republic
Vojtech Melenovsky - Department of Cardiology, IKEM, Prague, Czech Republic
Ivan Malek - Department of Cardiology, IKEM, Prague, Czech Republic
Antonij Slavcev - Department of Immunogenetics, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Michaela Bartonova - Department of Immunogenetics, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Vladimir Karmazin - Department of Cardiology, IKEM, Prague, Czech Republic
Tomas Eckhardt - Department of Cardiology, IKEM, Prague, Czech Republic
Ales Tomasek - Cardiovascular and Transplantation Surgery, Brno, Czech Republic
Eva Ozabalova - Department of Cardiovascular Diseases, St. Anne’s University Hospital and Masaryk University Brno, Czech Republic
Tomas Kovarnik - 2nd Department of Internal Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
Peter Wohlfahrt - Center for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic
Milan Sonka - Iowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Transplant immunology, Vol.65, pp.101340-101340
DOI: 10.1016/j.trim.2020.101340
PMID: 33069814
NLM abbreviation: Transpl Immunol
ISSN: 0966-3274
eISSN: 1878-5492
Publisher: Elsevier B.V
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/501100003243, name: Ministerstvo Zdravotnictví Ceské Republiky
Language: English
Date published: 04/2021
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
Record Identifier: 9984101222702771

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