Donor-to-host transmission of Candida albicans after corneal transplantation

John E Sutphin; Michael A Pfaller; Richard J Hollis; Michael D Wagoner

doi:10.1016/S0002-9394(02)01427-7

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Donor-to-host transmission of Candida albicans after corneal transplantation

Journal article

Peer reviewed

Donor-to-host transmission of Candida albicans after corneal transplantation

John E Sutphin, Michael A Pfaller, Richard J Hollis and Michael D Wagoner

American journal of ophthalmology, Vol.134(1), pp.120-121

07/2002

DOI: 10.1016/S0002-9394(02)01427-7

PMID: 12095820

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Abstract

To report donor-to-host transmission of Candida albicans after penetrating keratoplasty. Interventional case report. A 15-year-old boy who underwent penetrating keratoplasty for keratoconus with donor tissue from a drowning victim developed keratitis and a lenticular abscess 26 days postoperatively. Candida albicans was cultured from the donor rim and the recipient cornea. Antifungal sensitivity profiles were identical for the two isolates. DNA profiles were identical for both isolates, confirming the donor as the source of the infection. This case demonstrates the value of routine culture of corneal donor rims and the advisability of close follow-up and possible antifungal prophylaxis when donor rims are positive for fungus.

Candidiasis - transmission

Recurrence

Keratitis - microbiology

Humans

Male

Candidiasis - microbiology

Antifungal Agents - therapeutic use

Candida albicans - genetics

Microbial Sensitivity Tests

Candida albicans - drug effects

Candida albicans - isolation & purification

Disease Transmission, Infectious

Eye Infections, Fungal - transmission

Keratoplasty, Penetrating - adverse effects

Reoperation

DNA, Fungal - analysis

Combined Modality Therapy

Eye Infections, Fungal - therapy

Eye Infections, Fungal - microbiology

Keratoconus - surgery

Adolescent

Candidiasis - therapy

Tissue Donors

Amphotericin B - therapeutic use

Keratitis - therapy

Details

Title: Subtitle: Donor-to-host transmission of Candida albicans after corneal transplantation
Creators: John E Sutphin - Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City 52242-1091, USA. sutphinj@horus.ophth.uiowa.edu
Michael A Pfaller
Richard J Hollis
Michael D Wagoner
Resource Type: Journal article
Publication Details: American journal of ophthalmology, Vol.134(1), pp.120-121
Publisher: United States
DOI: 10.1016/S0002-9394(02)01427-7
PMID: 12095820
ISSN: 0002-9394
eISSN: 1879-1891
Language: English
Date published: 07/2002
Academic Unit: Epidemiology; Pathology; Ophthalmology and Visual Sciences
Record Identifier: 9983980387702771

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