Donor type, social deprivation, and long-term outcomes in pediatric liver transplantation: A 30-year population-based cohort

Toshifumi Yodoshi; M. Ellen Kuenzig; Furong Tang; Mari Kajiwara Saito; Andreanne Zizzo; Vicky L. Ng; Eric I. Benchimol

doi:10.1097/LVT.0000000000000877

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Donor type, social deprivation, and long-term outcomes in pediatric liver transplantation: A 30-year population-based cohort

Journal article

Peer reviewed

Donor type, social deprivation, and long-term outcomes in pediatric liver transplantation: A 30-year population-based cohort

Toshifumi Yodoshi, M. Ellen Kuenzig, Furong Tang, Mari Kajiwara Saito, Andreanne Zizzo, Vicky L. Ng and Eric I. Benchimol

Liver transplantation, 41974042

04/10/2026

DOI: 10.1097/LVT.0000000000000877

PMID: 41974042

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Abstract

Living donor liver transplantation (LDLT) reduces wait-list mortality in children, but its long-term advantages over deceased donor liver transplantation (DDLT) and how socioeconomic context shapes outcomes in a universal healthcare system remain uncertain. We compared long-term outcomes after pediatric LDLT versus DDLT and evaluated modification by socioeconomic status (SES). We linked clinical data for pediatric liver transplants in Ontario, Canada, from 1991 to 2021 to provincial health administrative data, yielding 449 recipients (189 LDLT, 260 DDLT) who underwent their first transplant. Over the 30-year period, LDLT recipients had superior patient and graft survival. After adjustment, DDLT was associated with a higher risk of mortality [adjusted hazard ratio (aHR) 2.1, 95% CI 1.0-4.3], graft failure (aHR 2.1, 95% CI 1.0-4.3), and chronic kidney disease (adjusted subdistribution HR 5.3, 95% CI 1.4-15.3), compared with LDLT. SES profoundly modified long-term outcomes: among DDLT recipients, lower neighborhood income and higher material deprivation were strongly linked to worse survival and increased graft loss. In contrast, LDLT moderated these socioeconomic disadvantages, with recipients showing comparable outcomes regardless of their SES (p for interaction <0.01). In this population-based cohort study, LDLT was associated with significantly better long-term patient and graft survival and a lower risk of chronic kidney disease compared with DDLT. Socioeconomic disadvantage negatively impacted outcomes primarily among DDLT recipients, highlighting the need to improve equitable access to LDLT and to strengthen targeted post-transplant support for socioeconomically vulnerable families.

Surgery

Gastroenterology & Hepatology

Life Sciences & Biomedicine

Science & Technology

Transplantation

Details

Title: Subtitle: Donor type, social deprivation, and long-term outcomes in pediatric liver transplantation: A 30-year population-based cohort
Creators: Toshifumi Yodoshi - Cincinnati Children's Hospital Medical Center
M. Ellen Kuenzig - Western University
Furong Tang - SickKids Foundation
Mari Kajiwara Saito - University of London
Andreanne Zizzo - Western University
Vicky L. Ng - University of Toronto
Eric I. Benchimol - University of Toronto
Resource Type: Journal article
Publication Details: Liver transplantation, 41974042
DOI: 10.1097/LVT.0000000000000877
PMID: 41974042
NLM abbreviation: Liver Transpl
ISSN: 1527-6465
eISSN: 1527-6473
Publisher: Lippincott Williams & Wilkins
Number of pages: 13
Language: English
Electronic publication date: 04/10/2026
Academic Unit: Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9985217143902771

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