Journal article
Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons
Neuron (Cambridge, Mass.), Vol.108(6), pp.1091-1102.e5
12/23/2020
DOI: 10.1016/j.neuron.2020.09.028
PMCID: 7769890
PMID: 33080228
Abstract
Corticostriatal synaptic integration is partitioned among striosome (patch) and matrix compartments of the dorsal striatum, allowing compartmentalized control of discrete aspects of behavior. Despite the significance of such organization, it’s unclear how compartment-specific striatal output is dynamically achieved, particularly considering new evidence that overlap of afferents is substantial. We show that dopamine oppositely shapes responses to convergent excitatory inputs in mouse striosome and matrix striatal spiny projection neurons (SPNs). Activation of postsynaptic D1 dopamine receptors promoted the generation of long-lasting synaptically evoked “up-states” in matrix SPNs but opposed it in striosomes, which were more excitable under basal conditions. Differences in dopaminergic modulation were mediated, in part, by dendritic voltage-gated calcium channels (VGCCs): pharmacological manipulation of L-type VGCCs reversed compartment-specific responses to D1 receptor activation. These results support a novel mechanism for the selection of striatal circuit components, where fluctuating levels of dopamine shift the balance of compartment-specific striatal output.
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•Both striosome and matrix dSPNs support dendritically evoked somatic “up-states”•Dopamine oppositely modulates up-state length in striosome versus matrix dSPNs via D1Rs•Compartment-specific responses to D1R activation involve L-type Ca2+ channels•Changes in striatal dopamine may shift the balance of striosome versus matrix output
Prager et al. show that dopamine promotes the maintenance of dendritically evoked “up-states” in mouse direct pathway matrix SPNs but opposes it in striosomes. This requires postsynaptic D1 receptors and involves differential engagement of L-type Ca2+ channels. These findings reveal a mechanism where fluctuations in dopamine may constrain compartment-specific striatal output.
Details
- Title: Subtitle
- Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons
- Creators
- Eric M. Prager - Stony Brook UniversityDaniel B. Dorman - George Mason UniversityZachary B. Hobel - Stony Brook UniversityJeffrey M. Malgady - Stony Brook UniversityKim T. Blackwell - George Mason UniversityJoshua L. Plotkin - Stony Brook University
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.108(6), pp.1091-1102.e5
- DOI
- 10.1016/j.neuron.2020.09.028
- PMID
- 33080228
- PMCID
- 7769890
- NLM abbreviation
- Neuron
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000027, name: National Institute on Alcohol Abuse and Alcoholism; DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000065, name: National Institute of Neurological Disorders and Stroke; DOI: 10.13039/100000874, name: Brain and Behavior Research Foundation
- Language
- English
- Date published
- 12/23/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984446439102771
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