Journal article
Dopaminergic and noradrenergic modulation of amphetamine-induced changes in auditory gating
Brain research, Vol.555(1), pp.91-98
1991
DOI: 10.1016/0006-8993(91)90864-R
PMID: 1681997
Abstract
Dopaminergic and noradrenergic mediation of central sensory gating were assessed in Sprague-Dawley rats using a condition-test paradigm in which auditory evoked potentials were recorded. In this paradigm, unmedicated rats ‘gate’, i.e. suppress the response to the second of a pair of clicks delivered at a 0.5 s interval. Amphetamine-treated rats fail to gate; in this respect, they resemble schizophrenic humans. Previous studies had indicated noradrenergic involvement in the mediation of auditory gating in rats. In this study, we used selective antagonists to assess the contribution of α- and β-adrenergic receptors, and dopamine D
1- and D the α-antagonist, phentolamine, and the β-antagonist, timolol, normalized gating by potentiating amphetamine-induced decreases in the amplitude of the test response. SCH 23390, a D
1-receptor antagonist, also normalized gating, but by elevating the amphetamine-reduced amplitude of the conditioning response. Sulpiride did not significantly alter amphetamine-induced changes in gating. Thus, both noradrenergic α- and β-receptors and dopamine D
1-receptors appear to modulate gating. However, their dissimilar means of normalizing gating suggests that noradrenergic and dopaminergic drugs act via different mechanisms and possibly different neuroanatomical loci.
Details
- Title: Subtitle
- Dopaminergic and noradrenergic modulation of amphetamine-induced changes in auditory gating
- Creators
- Karen E. Stevens - University of Colorado HealthLaura L. Fuller - United States Department of Veterans AffairsGreg M. Rose - United States Department of Veterans Affairs
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.555(1), pp.91-98
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(91)90864-R
- PMID
- 1681997
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1991
- Academic Unit
- Psychiatry; Urology
- Record Identifier
- 9984289768702771
Metrics
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