Journal article
Dopaminergic neurons encode a distributed, asymmetric representation of temperature in Drosophila
The Journal of neuroscience, Vol.33(5), pp.2166-2176
01/30/2013
DOI: 10.1523/JNEUROSCI.3933-12.2013
PMCID: PMC3711641
PMID: 23365252
Abstract
Dopaminergic circuits modulate a wide variety of innate and learned behaviors in animals, including olfactory associative learning, arousal, and temperature-preference behavior. It is not known whether distinct or overlapping sets of dopaminergic neurons modulate these behaviors. Here, I have functionally characterized the dopaminergic circuits innervating the Drosophila mushroom body with in vivo calcium imaging and conditional silencing of genetically defined subsets of neurons. Distinct subsets of PPL1 dopaminergic neurons innervating the vertical lobes of the mushroom body responded to decreases in temperature, but not increases, with rapidly adapting bursts of activity. PAM neurons innervating the horizontal lobes did not respond to temperature shifts. Ablation of the antennae and maxillary palps reduced, but did not eliminate, the responses. Genetic silencing of dopaminergic neurons innervating the vertical mushroom body lobes substantially reduced behavioral cold avoidance, but silencing smaller subsets of these neurons had no effect. These data demonstrate that overlapping dopaminergic circuits encode a broadly distributed, asymmetric representation of temperature that overlays regions implicated previously in learning, memory, and forgetting. Thus, diverse behaviors engage overlapping sets of dopaminergic neurons that encode multimodal stimuli and innervate a single anatomical target, the mushroom body.
Details
- Title: Subtitle
- Dopaminergic neurons encode a distributed, asymmetric representation of temperature in Drosophila
- Creators
- Seth M Tomchik - Scripps Research Institute
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.33(5), pp.2166-2176
- DOI
- 10.1523/JNEUROSCI.3933-12.2013
- PMID
- 23365252
- PMCID
- PMC3711641
- NLM abbreviation
- J Neurosci
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Grant note
- R00 MH092294 / NIMH NIH HHS K99 MH092294 / NIMH NIH HHS
- Language
- English
- Date published
- 01/30/2013
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984303853202771
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