Journal article
Dose Dependency for Absorption and Elimination Rates of Theophylline Implications for Studies of Bioavailability
Pharmacotherapy, Vol.4(4), pp.216-220
07/08/1984
DOI: 10.1002/j.1875-9114.1984.tb03361.x
PMID: 6483638
Abstract
Dose dependency for absorption and elimination rates of theophylline were examined by administering 2‐mg/kg and 6‐mg/kg doses of a theophylline solution to 8 adult volunteers. The area under the concentration‐time curve extrapolated to infinity after the lower dose was 84% of that calculated after the higher dose. This is associated with a decrease in the slope of the terminal portion of the elimination curve to varying degrees after the higher dose in all 8 patients (p < 0.001). A significantly smaller fraction of the higher dose was absorbed at 15 minutes (0.46 vs. 0.77, p < 0.002), but the differences were trivial by 30 to 45 minutes. Dose dependency for elimination may cause changes in a steady‐state serum concentration during multiple dosing that is disproportionately larger than changes in dosage. In addition, the slower elimination at higher serum concentrations may confound the assessment of bioavailability of slow‐release formulations when the doses used result in a substantial disparity in the range of serum concentrations attained for the slow‐release formulation and the reference. The use of unequal doses adjusted to provide similar peak serum concentrations appears to minimize this potential error. 1984 Pharmacotherapy Publications Inc.
Details
- Title: Subtitle
- Dose Dependency for Absorption and Elimination Rates of Theophylline Implications for Studies of Bioavailability
- Creators
- Gary Milavetz - University of IowaMiles Weinberger - University of IowaLeigh Vaughan - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Pharmacotherapy, Vol.4(4), pp.216-220
- Publisher
- Blackwell Publishing Ltd
- DOI
- 10.1002/j.1875-9114.1984.tb03361.x
- PMID
- 6483638
- ISSN
- 0277-0008
- eISSN
- 1875-9114
- Number of pages
- 5
- Language
- English
- Date published
- 07/08/1984
- Academic Unit
- Pharmacy; Stead Family Department of Pediatrics; Pharmacy Practice and Science
- Record Identifier
- 9984366015202771
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