Journal article
Dose-dependent modulation of systemic lipid peroxidation and activity of anti-oxidant enzymes by vitamin E in the rat
Redox report : communications in free radical research, Vol.13(2), pp.60-66
04/01/2008
DOI: 10.1179/135100008X259114
PMID: 18339248
Abstract
The objective of this work was to examine the time-dependent pro-oxidant versus antioxidant effect of various doses of vitamin E used commonly in experimental studies. Erythrocyte activity of superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT) and plasma lipid peroxidation levels were investigated following biweekly intramuscular administration of 100, 300 and 600 mg/kg of vitamin E at a baseline time point, and additionally at 2, 4 and 6 weeks after initiating treatment. Vitamin E had an antioxidant effect when administered at low doses over short time periods, and increased the activity of antioxidant enzymes. At higher doses and over longer time periods, it increased the level of lipid peroxidation, and attenuated the activity of antioxidant enzymes. These results suggest that time-dependent variations in vitamin E effects should be considered in design and interpretation of experimental antioxidant studies, as well as during clinical trials.
Details
- Title: Subtitle
- Dose-dependent modulation of systemic lipid peroxidation and activity of anti-oxidant enzymes by vitamin E in the rat
- Creators
- Maliheh Hajiani - Tehran University of Medical SciencesAbolfazl Golestani - Tehran University of Medical SciencesAhmad Shariftabrizi - Tehran University of Medical SciencesRoghieh Rastegar - Tehran University of Medical SciencesSeyedmehdi Payabvash - Tehran University of Medical SciencesAmirali Hassanzadeh Salmasi - Tehran University of Medical SciencesAhmad Reza Dehpour - Tehran University of Medical SciencesParvin Pasalar - Tehran University of Medical Sciences
- Resource Type
- Journal article
- Publication Details
- Redox report : communications in free radical research, Vol.13(2), pp.60-66
- DOI
- 10.1179/135100008X259114
- PMID
- 18339248
- NLM abbreviation
- Redox Rep
- ISSN
- 1351-0002
- eISSN
- 1743-2928
- Publisher
- Taylor & Francis
- Number of pages
- 7
- Language
- English
- Date published
- 04/01/2008
- Academic Unit
- Radiology
- Record Identifier
- 9984318815602771
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