Journal article
Dose-dependent use of dobutamine to alter early diastolic filling in normal subjects
The American journal of cardiology, Vol.62(4), pp.333-334
08/01/1988
DOI: 10.1016/0002-9149(88)90241-X
PMID: 3400616
Abstract
Pulsed Doppler echocardiography provides a noninvasive method for the evaluation of diastolic filling.1,2 Both peak early filling (E) velocity and the ratio of E velocity to peak late filling (A) velocity correlate with parameters of diastolic tilling obtained from cineangiography.3 However, the evaluation of diastolic filling may be altered by the addition of inotropic agents. Colan et al4 demonstrated that dobutamine administration to normal subjects increases the peak rate of diastolic left ventricular dimension change. The mechanism of this increased early filling may be multifactorial (i.e., due to direct effects on relaxation, or changes in arterial impedance or loading conditions related to enhanced systolic function, or both).4 Because enhanced systolic function may affect diastolic filling4 and because good linear correlations exist between dobutamine doses of 2.5 to 10.0 μg/kg/min and stroke volume,5 our purpose was to evaluate—in normal subjects—the effect of similar increasing doses of dobutamine on diastolic filling.
Details
- Title: Subtitle
- Dose-dependent use of dobutamine to alter early diastolic filling in normal subjects
- Creators
- Byron F VandenbergCraig A StarkJohn A RumbergerRichard E Kerber
- Resource Type
- Journal article
- Publication Details
- The American journal of cardiology, Vol.62(4), pp.333-334
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0002-9149(88)90241-X
- PMID
- 3400616
- ISSN
- 0002-9149
- eISSN
- 1879-1913
- Language
- English
- Date published
- 08/01/1988
- Academic Unit
- Radiology; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984094587502771
Metrics
16 Record Views