Journal article
Dose-related effects of perfluorodecanoic acid on growth, feed intake and hepatic peroxisomal β-oxidation
Archives of toxicology, Vol.66(1), pp.18-22
01/1992
DOI: 10.1007/BF02307265
PMID: 1580792
Abstract
The effects of the persistent peroxisome proliferator, perfluorodecanoic acid (PFDA), on growth, feed intake and the enzyme activities associated with peroxisomal beta-oxidation were studied in female Sprague Dawley rats. Rats received one of six levels of PFDA (0, 0.3, 1.0, 3.0, 10.0 or 30.0 mg/kg/injection) in four IP doses at 2-week intervals. Rats with cumulative doses of less than or equal to 12.0 mg/kg did not differ from control rats in growth or feed intake, while rats receiving cumulative doses of greater than or equal to mg/kg lost weight and decreased their feed intake. Rats which received cumulative doses between these levels increased their feed intake but did not significantly alter their body weight. Total peroxisomal beta-oxidation was decreased in a dose-related manner, whereas the liver to body weight ratio and the activities of individual enzymes comprising the peroxisomal beta-oxidation system, namely fatty acyl-CoA oxidase, enoyl-CoA hydratase, 3-hydroxy-acyl-CoA dehydrogenase, and thiolase, were increased. This study clearly shows that the inhibition of peroxisomal beta-oxidation by PFDA is not reflected in the in vitro measurement of the individual enzyme activities comprising this pathway.
Details
- Title: Subtitle
- Dose-related effects of perfluorodecanoic acid on growth, feed intake and hepatic peroxisomal β-oxidation
- Creators
- Tim BorgesLarry W RobertsonRichard E PetersonHoward P Glauert
- Resource Type
- Journal article
- Publication Details
- Archives of toxicology, Vol.66(1), pp.18-22
- DOI
- 10.1007/BF02307265
- PMID
- 1580792
- ISSN
- 0340-5761
- eISSN
- 1432-0738
- Language
- English
- Date published
- 01/1992
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984002420902771
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