Journal article
Dose-response relationship between maternal blood pressure in pregnancy and risk of adverse birth outcomes: Ma’anshan birth cohort study
Pregnancy hypertension, Vol.15, pp.16-22
01/2019
DOI: 10.1016/j.preghy.2018.09.004
PMID: 30825914
Abstract
•Both maternal systolic and/or diastolic blood pressures (SBP and/or DBP) during pregnancy were related to the risk of small for gestational age (SGA) and/or pre-term birth (PTB) in a dose-response manner.•Even blood pressure within a normal range, those with SBP of 125 mm Hg or above and DBP of 80 mm Hg or above, already had a higher risk of SGA and/or PTB.•Different adverse birth outcomes might have different sensitive periods.•The magnitude of associations between higher BP and adverse birth outcomes increased over time, with the strongest associations observed in the third trimester.
This study depicts the dose-response relationship between blood pressure (BP) during pregnancy and adverse birth outcomes in different trimesters.
We used restricted cubic spline to quantify the dose-response relationship between maternal BP in different trimesters and risk of adverse birth outcomes (small for gestational age, SGA; and pre-term birth, PTB). The data were from the Ma’anshan birth cohort study in China (N = 3273).
Risk of SGA and PTB.
There were dose-response associations of both systolic blood pressure (SBP) and diastolic blood pressure (DBP) with risk of SGA in the third trimester and with PTB in both second and third trimesters. In the third trimester, compared with SBP of 120 mmHg, the odds ratios (ORs) and 95% confidence intervals (CI) of SGA were 1.12 (1.01–1.19), 1.32 (1.10–1.60), 1.65 (1.20–2.27) and 2.05 (1.30–3.24) for SBP of 125, 130, 135 and 140 mmHg, respectively. The corresponding ORs and 95% CIs of PTB were 1.15 (1.00–1.32), 1.59 (1.28–1.98), 2.35 (1.66–3.33) and 3.47 (2.10–5.73), respectively. Compared with DBP of 70 mmHg, the ORs and 95% CIs of SGA were 1.44 (1.16–1.78) and 3.04 (2.06–4.50) for DBP of 80 and 90 mmHg, respectively. The corresponding ORs and 95% CIs of PTB were 1.32 (0.93–1.90) and 3.58 (2.21–5.78), respectively.
A consistent set of dose-response relationships between maternal BP and adverse birth outcomes were observed. Most importantly, we found that moderately elevated maternal BP, even within a normal range, increased the risk of adverse birth outcomes.
Details
- Title: Subtitle
- Dose-response relationship between maternal blood pressure in pregnancy and risk of adverse birth outcomes: Ma’anshan birth cohort study
- Creators
- Beibei Zhu - Department of Maternal, Child & Adolescent Health, Anhui Medical University, Hefei, ChinaKun Huang - Department of Maternal, Child & Adolescent Health, Anhui Medical University, Hefei, ChinaWei Bao - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USAShuangqin Yan - Ma’anshan Maternal and Child Health Care Center, Ma’anshan, ChinaJiahu Hao - Department of Maternal, Child & Adolescent Health, Anhui Medical University, Hefei, ChinaPeng Zhu - Department of Maternal, Child & Adolescent Health, Anhui Medical University, Hefei, ChinaHui Gao - Department of Maternal, Child & Adolescent Health, Anhui Medical University, Hefei, ChinaYing Niu - Department of Maternal, Child & Adolescent Health, Anhui Medical University, Hefei, ChinaShilu Tong - Anhui Provincial Key Laboratory of Population Health & Aristogenics, Anhui Medical University, Hefei, ChinaFangbiao Tao - Department of Maternal, Child & Adolescent Health, Anhui Medical University, Hefei, China
- Resource Type
- Journal article
- Publication Details
- Pregnancy hypertension, Vol.15, pp.16-22
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.preghy.2018.09.004
- PMID
- 30825914
- ISSN
- 2210-7789
- eISSN
- 2210-7797
- Grant note
- DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 81330068; DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 81573168
- Language
- English
- Date published
- 01/2019
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983995014002771
Metrics
35 Record Views