Logo image
Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans
Journal article   Peer reviewed

Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans

Antoine Bechara, Daniel Tranel, Hanna Damasio, Ralph Adolphs, Charles Rockland and Antonio R Damasio
Science (American Association for the Advancement of Science), Vol.269(5227), pp.1115-1118
08/25/1995
DOI: 10.1126/science.7652558
PMID: 7652558

View Online

Abstract

A patient with selective bilateral damage to the amygdala did not acquire conditioned autonomic responses to visual or auditory stimuli but did acquire the declarative facts about which visual or auditory stimuli were paired with the unconditioned stimulus. By contrast, a patient with selective bilateral damage to the hippocampus failed to acquire the facts but did acquire the conditioning. Finally, a patient with bilateral damage to both amygdala and hippocampal formation acquired neither the conditioning nor the facts. These findings demonstrate a double dissociation of conditioning and declarative knowledge relative to the human amygdala and hippocampus.
Acoustic Stimulation Humans Middle Aged Autonomic Nervous System - physiology Male Hippocampus - pathology Amygdala - pathology Learning Galvanic Skin Response Brain Diseases - pathology Conditioning (Psychology) Adult Female Hippocampus - physiology Photic Stimulation Amygdala - physiology Brain Diseases - psychology

Details

Logo image