Journal article
Doxepin kinetics
Clinical pharmacology and therapeutics, Vol.23(5), pp.573-579
05/1978
DOI: 10.1002/cpt1978235573
PMID: 639432
Abstract
The kinetics of doxepin (DOX) hydrochloride were studied in 7 volunteers after the oral administration of 75 mg. Peak plasma concentrations of DOX ranged from 8.8 to 45.8 ng/ml and were reached within 4 hr. The disappearance of DOX was biphasic and followed first‐order kinetics. The mean DOX half life (t½) was 16.8 hr and in individuals ranged from 8.2 to 24.5 hr. The mean apparent volume of distribution was 20.2 L/kg and ranged from 9.1 to 33.3 L/kg. The estimated first‐pass metabolism of DOX ranged from 55% to 87% of the oral dose assuming complete absorption. Significant quantities of the metabolite desmethyldoxepin (DMD) were produced. Peak levels of DMD ranged from 4.8 to 14.5 ng/ml and were reached between 2 and 10 hr after administration. The mean tl½ of DMD was 51.3 hr and in individuals ranged from 33.2 to 80.7 hr. There was no correlation between the DOX and DMD t½s. The amount of DMD produced correlated with the plasma concentration of DOX and appears to explain the correlation between the steady‐state concentrations of DOX and DMD in patients given DOX.
Details
- Title: Subtitle
- Doxepin kinetics
- Creators
- Vincent E ZieglerJohn T BiggsLaurence T WylieSamuel H RosenDonald J HawfWilliam H Coryell
- Resource Type
- Journal article
- Publication Details
- Clinical pharmacology and therapeutics, Vol.23(5), pp.573-579
- DOI
- 10.1002/cpt1978235573
- PMID
- 639432
- ISSN
- 0009-9236
- eISSN
- 1532-6535
- Number of pages
- 7
- Language
- English
- Date published
- 05/1978
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003447602771
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