Doxycycline reduces early neurologic impairment after cerebral arterial air embolism in the rabbit

D K Reasoner; B J Hindman; F Dexter; A Subieta; J Cutkomp; T Smith

doi:10.1097/00000542-199709000-00017

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Doxycycline reduces early neurologic impairment after cerebral arterial air embolism in the rabbit

Journal article

Open access

Peer reviewed

Doxycycline reduces early neurologic impairment after cerebral arterial air embolism in the rabbit

D K Reasoner, B J Hindman, F Dexter, A Subieta, J Cutkomp and T Smith

Anesthesiology, Vol.87(3), pp.569-576

09/1997

DOI: 10.1097/00000542-199709000-00017

PMID: 9316962

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Abstract

Previous studies indicate leukocytes play a role in the pathogenesis of cerebral arterial air embolism. Because doxycycline inhibits numerous leukocyte activities, the authors hypothesized doxycycline would decrease neurologic impairment after cerebral arterial air embolism. New Zealand White rabbits anesthetized with methohexital received either intravenous saline (n = 7) or 10 mg/kg doxycycline (n = 7) 1 h before administration of 100 microl/kg of air into the internal carotid artery. Somatosensory-evoked potentials (SSEPs) were recorded at 30-min intervals for the next 2 h. After the final recording, the anesthetic was discontinued, and animals recovered. Animals were neurologically evaluated 4 h after air embolism on a scale of 0 (normal) to 99 (coma) points. At 4 h, doxycycline animals had lesser neurologic impairment (46 +/- 23; median, 41) than animals that received saline (77 +/- 20; median, 81); P = 0.007. SSEP amplitude was greater in the doxycycline group at 60, 90, and 120 min after air embolism; P = 0.001, 0.006, 0.026, respectively. SSEP amplitudes at 30, 60, 90, and 120 min inversely correlated with 4 h neurologic impairment; tau = -0.43, -0.75, -0.85, -0.79, respectively. Doxycycline decreased electrophysiologic and neurologic abnormalities after cerebral air embolism. Because groups could be distinguished electrophysiologically as soon as 1 h after air embolism and because SSEP amplitude inversely correlated with neurologic impairment, doxycycline appears to inhibit a key early (approximately 1 h) process in the pathophysiology of cerebral air embolism.

Rabbits

Evoked Potentials, Somatosensory - drug effects

Male

Nitric Oxide - physiology

Brain Ischemia - physiopathology

Leukocytes - physiology

Tetracyclines - pharmacology

Animals

Intracranial Embolism and Thrombosis - physiopathology

Embolism, Air - physiopathology

Doxycycline - pharmacology

Female

Embolism, Air - drug therapy

Intracranial Embolism and Thrombosis - drug therapy

Details

Title: Subtitle: Doxycycline reduces early neurologic impairment after cerebral arterial air embolism in the rabbit
Creators: D K Reasoner - Department of Anesthesia, University of Iowa, College of Medicine, Iowa City 52242, USA
B J Hindman
F Dexter
A Subieta
J Cutkomp
T Smith
Resource Type: Journal article
Publication Details: Anesthesiology, Vol.87(3), pp.569-576
DOI: 10.1097/00000542-199709000-00017
PMID: 9316962
NLM abbreviation: Anesthesiology
ISSN: 0003-3022
eISSN: 1528-1175
Publisher: United States
Language: English
Date published: 09/1997
Academic Unit: Health Management and Policy; Anesthesia
Record Identifier: 9983806290302771

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