Journal article
Draft Genome Sequence of the Sexually Transmitted Pathogen Trichomonas vaginalis
Science (American Association for the Advancement of Science), Vol.315(5809), pp.207-212
01/12/2007
DOI: 10.1126/science.1132894
PMCID: PMC2080659
PMID: 17218520
Abstract
We describe the genome sequence of the protist
Trichomonas vaginalis
, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ~160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.
Details
- Title: Subtitle
- Draft Genome Sequence of the Sexually Transmitted Pathogen Trichomonas vaginalis
- Creators
- Jane M Carlton - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKRobert P Hirt - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKJoana C Silva - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKArthur L Delcher - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKMichael Schatz - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKQi Zhao - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKJennifer R Wortman - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKShelby L Bidwell - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKU. Cecilia M Alsmark - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKSébastien Besteiro - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKThomas Sicheritz-Ponten - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKChristophe J Noel - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKJoel B Dacks - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKPeter G Foster - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKCedric Simillion - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKYves Van de Peer - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKDiego Miranda-Saavedra - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKGeoffrey J Barton - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKGareth D Westrop - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKSylke Müller - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKDaniele Dessi - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKPier Luigi Fiori - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKQinghu Ren - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKIan Paulsen - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKHanbang Zhang - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKFelix D Bastida-Corcuera - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKAugusto Simoes-Barbosa - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKMark T Brown - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKRichard D Hayes - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKMandira Mukherjee - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKCheryl Y Okumura - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKRachel Schneider - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKAlias J Smith - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKStepanka Vanacova - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKMaria Villalvazo - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKBrian J Haas - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKMihaela Pertea - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKTamara V Feldblyum - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKTerry R Utterback - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKChung-Li Shu - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKKazutoyo Osoegawa - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKPieter J de Jong - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKIvan Hrdy - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKLenka Horvathova - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKZuzana Zubacova - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKPavel Dolezal - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKShehre-Banoo Malik - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKJohn M Logsdon - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKKatrin Henze - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKArti Gupta - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKChing C Wang - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKRebecca L Dunne - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKJacqueline A Upcroft - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKPeter Upcroft - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKOwen White - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKSteven L Salzberg - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKPetrus Tang - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKCheng-Hsun Chiu - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKYing-Shiung Lee - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKT. Martin Embley - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKGraham H Coombs - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKJeremy C Mottram - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKJan Tachezy - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKClaire M Fraser-Liggett - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UKPatricia J Johnson - Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Technologiepark 927, B-9052 Ghent, Belgium School of Life Sciences Research, University of Dundee, Dow Street, Dundee DD1 5EH, UK Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095–1489, USA J. Craig Venter Joint Technology Center, 5 Research Place, Rockville, MD 20850, USA Children’s Hospital Oakland Research Institute, 747 52nd Street, Oakland, CA 94609, USA Department of Parasitology, Faculty of Science, Charles University, 128 44 Prague, Czech Republic Department of Biological Sciences, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242–1324, USA Institute of Botany, Heinrich Heine University, 40225 Düsseldorf, Germany Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143–2280, USA Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia Bioinformatics Center/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Medical Genomic Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan Strathclyde Institute of Pharmacy and Biomedical Sciences, John Arbuthnott Building, University of Strathclyde, Glasgow G4 0NR, UK
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.315(5809), pp.207-212
- DOI
- 10.1126/science.1132894
- PMID
- 17218520
- PMCID
- PMC2080659
- NLM abbreviation
- Science
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 01/12/2007
- Academic Unit
- Biology
- Record Identifier
- 9984217413302771
Metrics
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