Drinking and arterial blood pressure responses to ANG II in young and old rats

Robert L Thunhorst; Terry G Beltz; Alan Kim Johnson

doi:10.1152/ajpregu.00360.2010

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Drinking and arterial blood pressure responses to ANG II in young and old rats

Journal article

Open access

Peer reviewed

Drinking and arterial blood pressure responses to ANG II in young and old rats

Robert L Thunhorst, Terry G Beltz and Alan Kim Johnson

American journal of physiology. Regulatory, integrative and comparative physiology, Vol.299(5), pp.R1135-1141

11/2010

DOI: 10.1152/ajpregu.00360.2010

PMCID: PMC2980447

PMID: 20739604

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Abstract

We investigated water drinking and arterial blood pressure responses to intravenous infusions of ANG II in young (4 mo), middle-aged adult (12 mo), and old (29 mo) male Brown Norway rats. Infusions of ANG II began with arterial blood pressure either at control levels or at reduced levels following injection of the vasodilator minoxidil. Under control conditions, mean arterial pressure (MAP) in response to ANG II rose to the same level for all groups, and middle-aged and old rats drank as much or more water in response to ANG II compared with young rats, depending on whether intakes were analyzed using absolute or body weight-adjusted values. When arterial blood pressure first was reduced with minoxidil, MAP in response to ANG II stabilized at significantly lower levels compared with control conditions for all groups. Young rats drank significantly more water under reduced pressure conditions compared with control conditions, while middle-aged and old rats did not. Urine volume in response to ANG II was lower, while water balance was higher, under conditions of reduced pressure compared with control conditions. Baroreflex control of heart rate was substantially reduced in old rats compared with young and middle-aged animals. In summary, young rats appear to be more sensitive to the inhibitory effects of increased arterial blood pressure on water drinking than are older animals.

Adaptation, Physiological

Age Factors

Angiotensin II - administration & dosage

Angiotensin I - administration & dosage

Rats

Urodynamics - drug effects

Male

Water-Electrolyte Balance - drug effects

Angiotensin-Converting Enzyme Inhibitors - administration & dosage

Rats, Sprague-Dawley

Baroreflex - drug effects

Dose-Response Relationship, Drug

Heart Rate - drug effects

Rats, Inbred BN

Captopril - administration & dosage

Animals

Minoxidil - administration & dosage

Aging

Behavior, Animal - drug effects

Drinking Behavior - drug effects

Blood Pressure - drug effects

Drinking - drug effects

Infusions, Intravenous

Vasodilator Agents - administration & dosage

Details

Title: Subtitle: Drinking and arterial blood pressure responses to ANG II in young and old rats
Creators: Robert L Thunhorst - Dept. of Psychology, Univ. of Iowa, 11 Seashore Hall E., Iowa City, IA 52242-1407, USA. robert-thunhorst@uiowa.edu
Terry G Beltz
Alan Kim Johnson
Resource Type: Journal article
Publication Details: American journal of physiology. Regulatory, integrative and comparative physiology, Vol.299(5), pp.R1135-1141
DOI: 10.1152/ajpregu.00360.2010
PMID: 20739604
PMCID: PMC2980447
NLM abbreviation: Am J Physiol Regul Integr Comp Physiol
ISSN: 0363-6119
eISSN: 1522-1490
Publisher: American Physiological Society; United States
Grant note: R01 MH080241 / NIMH NIH HHS MH-59239 / NIMH NIH HHS R01 HL098207 / NHLBI NIH HHS AG-25465 / NIA NIH HHS DK-66086 / NIDDK NIH HHS HL-57472 / NHLBI NIH HHS HL-14388 / NHLBI NIH HHS R01 AG025465 / NIA NIH HHS
Language: English
Date published: 11/2010
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984002321202771

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