Drinking water disinfection byproducts and risk of orofacial clefts in the National Birth Defects Prevention Study

Peter Weyer; Anthony Rhoads; Jonathan Suhl; Thomas J Luben; Kristin M Conway; Peter H Langlois; Dereck Shen; Dong Liang; Soman Puzhankara; Marlene Anderka; Erin Bell; Marcia L Feldkamp; Adrienne T Hoyt; Bridget Mosley; Jennita Reefhuis; Paul A Romitti; National Birth Defects Prevention Study

doi:10.1002/bdr2.1348

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Drinking water disinfection byproducts and risk of orofacial clefts in the National Birth Defects Prevention Study

Journal article

Open access

Peer reviewed

Drinking water disinfection byproducts and risk of orofacial clefts in the National Birth Defects Prevention Study

Peter Weyer, Anthony Rhoads, Jonathan Suhl, Thomas J Luben, Kristin M Conway, Peter H Langlois, Dereck Shen, Dong Liang, Soman Puzhankara, Marlene Anderka, …

Birth defects research, Vol.110(12), pp.1027-1042

07/17/2018

DOI: 10.1002/bdr2.1348

PMCID: PMC6375538

PMID: 30133956

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https://www.ncbi.nlm.nih.gov/pmc/articles/6375538View

Open Access

Abstract

Background Maternal exposure to drinking water disinfection byproducts (DBP)s may contribute to orofacial cleft (OFC) development, but studies are sparse and beset with limitations. Methods Population-based, maternal interview reports of drinking water filtration and consumption for 680 OFC cases (535 isolated) and 1826 controls were linked with DBP concentration data using maternal residential addresses and public water system monitoring data. Maternal individual-level exposures to trihalomethanes (THM)s and haloacetic acids (HAA)s (µg/L of water consumed) were estimated from reported consumption at home, work, and school. Compared to no exposure, associations with multisource maternal exposure <1/2 or ≥1/2 the Maximum Contaminant Levels (MCL)s for total THMs (TTHM)s and HAAs (HAA5) or Maximum Contaminant Level Goals (MCLG)s for individual THMs and HAAs (if non-zero) were estimated for all OFCs and isolated OFCs, cleft palate (CP), and cleft lip ± cleft palate (CL/P) using logistic regression analyses. Results Compared to controls, associations were near or below unity for maternal TTHM, HAA5, and individual THM exposures with all OFCs and isolated OFCs, CP, and CL/P. Associations also were near or below unity for individual HAAs with statistically significant, inverse associations observed with each OFC outcome group except CL/P. Conclusions This study examined associations for maternal reports of drinking water filtration and consumption and maternal DBP exposure from drinking water with OFCs in offspring. Associations observed were near or below unity and mostly nonsignificant. Continued, improved research using maternal individual-level exposure data will be useful in better characterizing these associations.

Humans

Risk Factors

Disinfection

Male

Brain - abnormalities

Maternal Exposure

Drinking Water - adverse effects

Cleft Palate - prevention & control

Acetates - analysis

Cleft Palate - etiology

Female

Trihalomethanes - analysis

Cleft Lip - prevention & control

Odds Ratio

Infant, Newborn

Cleft Lip - etiology

Details

Title: Subtitle: Drinking water disinfection byproducts and risk of orofacial clefts in the National Birth Defects Prevention Study
Creators: Peter Weyer - Center for Health Effects of Environmental Contamination, Office of the Vice President for Research and Economic Development, University of Iowa, Iowa City, Iowa
Anthony Rhoads - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa
Jonathan Suhl - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa
Thomas J Luben - National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina
Kristin M Conway - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa
Peter H Langlois - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas
Dereck Shen - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa
Dong Liang - Environmental Statistics Collaborative, Chesapeake Biological Laboratories, University of Maryland Center for Environmental Science, Solomons, Maryland
Soman Puzhankara - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa
Marlene Anderka - Center for Birth Defects Research and Prevention at the Massachusetts Department of Public Health, Boston, Massachusetts
Erin Bell - Department of Epidemiology and Biostatistics, School of Public Health, State University of New York at Albany, Rensselaer, New York
Marcia L Feldkamp - Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah
Adrienne T Hoyt - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas
Bridget Mosley - Department of Pediatrics, Arkansas Children's Hospital, Little Rock, Arkansas
Jennita Reefhuis - Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia
Paul A Romitti - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: Birth defects research, Vol.110(12), pp.1027-1042
DOI: 10.1002/bdr2.1348
PMID: 30133956
PMCID: PMC6375538
NLM abbreviation: Birth Defects Res
ISSN: 2472-1727
eISSN: 2472-1727
Publisher: Wiley; United States
Grant note: P30 ES005605 / NIEHS NIH HHS U01DD001035 / ACL HHS U01 DD001035 / NCBDD CDC HHS EPA999999 / Intramural EPA
Language: English
Date published: 07/17/2018
Academic Unit: Occupational and Environmental Health; Epidemiology; Biostatistics
Record Identifier: 9983995005202771

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