Drinking water source and chlorination byproducts in Iowa. III. Risk of brain cancer

Kenneth P Cantor; Charles F Lynch; Mariana E Hildesheim; Mustafa Dosemeci; Jay Lubin; Michael Alavanja; Gunther Craun

doi:10.1093/oxfordjournals.aje.a010052

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Drinking water source and chlorination byproducts in Iowa. III. Risk of brain cancer

Journal article

Open access

Peer reviewed

Drinking water source and chlorination byproducts in Iowa. III. Risk of brain cancer

Kenneth P Cantor, Charles F Lynch, Mariana E Hildesheim, Mustafa Dosemeci, Jay Lubin, Michael Alavanja and Gunther Craun

American journal of epidemiology, Vol.150(6), pp.552-560

09/15/1999

DOI: 10.1093/oxfordjournals.aje.a010052

PMID: 10489993

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Abstract

The authors conducted a population-based case-control study in Iowa of 375 brain cancer patients and 2,434 controls. A postal questionnaire was used to gather information on lifetime residential history, sources of drinking water, beverage intake, and other potential risk factors. Exposure to chlorination byproducts in drinking water was estimated by combining questionnaire data with historical information from water utilities and trihalomethane levels in recent samples. The analysis included 291 cases (77.6%) and 1,983 controls (81.5%), for whom water quality information was available for at least 70% of lifetime years. Proxies represented 74.4% of cases. The mean number and mean duration of places of residence were comparable between direct and proxy respondents, suggesting little contribution to bias. After multivariate adjustment, odds ratios for brain cancer were 1.0, 1.1, 1.6, and 1.3 for exposure to chlorinated surface water of 0, 1-19, 20-39, and > or =40 years (p trend = 0.1). Among men, odds ratios were 1.0, 1.3, 1.7, and 2.5 (p trend = 0.04), and among women, 1.0, 1.0, 1.6, and 0.7 (p trend = 0.7)). Similar findings were found with estimates of average lifetime level of trihalomethanes. The association was stronger among men with above-median tap water consumption. These observations deserve further attention, especially in view of increasing glioma rates.

Chlorine - adverse effects

Brain Neoplasms - etiology

Glioma - etiology

Chlorofluorocarbons, Methane - analysis

Humans

Middle Aged

Risk Factors

Chlorine - analysis

Male

Water Purification

Glioma - epidemiology

Case-Control Studies

Incidence

Confounding Factors (Epidemiology)

Aged, 80 and over

Adult

Female

Iowa - epidemiology

Aged

Odds Ratio

Water Supply - analysis

Brain Neoplasms - epidemiology

Details

Title: Subtitle: Drinking water source and chlorination byproducts in Iowa. III. Risk of brain cancer
Creators: Kenneth P Cantor - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7240, USA
Charles F Lynch
Mariana E Hildesheim
Mustafa Dosemeci
Jay Lubin
Michael Alavanja
Gunther Craun
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.150(6), pp.552-560
DOI: 10.1093/oxfordjournals.aje.a010052
PMID: 10489993
NLM abbreviation: Am J Epidemiol
ISSN: 0002-9262
eISSN: 1476-6256
Publisher: United States
Grant note: 5 KO7 CA01181-05 / NCI NIH HHS N01-CP-51026 / NCI NIH HHS N01-CP-85614 / NCI NIH HHS
Language: English
Date published: 09/15/1999
Academic Unit: Epidemiology
Record Identifier: 9983995015102771

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